The AAA team: related ATPases with diverse functions
The AAA team: related ATPases with diverse functions
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DOI：
10.1016/s0962-8924(97)01212-9
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发表时间：
1998-02-01
影响因子：
19
通讯作者：
Latterich, M
中科院分区：
文献类型：
--
作者：
Patel, S;Latterich, M
出现了一个新的相关ATP酶家族，其特征在于高度保守的AAA基序。该基序形成一个230个氨基酸的结构域，该结构域含有步行者同源序列并赋予ATP酶活性。AAA家族成员之间的同源性主要局限于AAA结构域，尽管AAA基序之外的其他同源性存在于密切相关的蛋白质中。AAA蛋白在多种细胞功能中起作用，包括细胞周期调节、蛋白质降解、细胞器生物发生和囊泡介导的蛋白质转运。AAA结构域是蛋白质功能所必需的，但其确切作用和赋予AAA蛋白的特异性活性仍不清楚。本文综述了目前对AAA蛋白家族的了解。
A new family of related ATPases has emerged, characterized by a highly conserved AAA motif. This motif forms a 230-amino-acid domain that contains Walker homology sequences and imparts ATPase activity. Homology between AAA-family members is confined mostly to the AAA domain, although additional homology outside the AAA motif is present among closely related proteins. AAA proteins act in a variety of cellular functions, including cell-cycle regulation, protein degradation, organelle biogenesis and vesicle-mediated protein transport. The AAA domain is required for protein function, but ifs exact role and the specific activity that it confers on AAA proteins is still unclear. This review describes current understanding of the AAA protein family.