Unique features and emerging in vitro models of human placental development.
Unique features and emerging in vitro models of human placental development.
复制标题
DOI：
10.1002/rmb2.12347
复制
发表时间：
2020-10
影响因子：
3.4
通讯作者：
Arima T
中科院分区：
文献类型：
--
作者：
Shibata S;Kobayashi EH;Kobayashi N;Oike A;Okae H;Arima T
胎盘是哺乳动物胎儿正常发育的重要器官。我们对胎盘发育的分子机制的认识大多来自于对小鼠的分析，特别是对基因敲除小鼠的组织病理学检查。绒毛膜癌和永生化细胞系也被用于人类胎盘的基础研究。然而，这些细胞与正常的滋养层细胞有很大的不同。在这篇综述中，我们首先提供了一个概述小鼠和人类胎盘的发展，特别侧重于这些物种之间的解剖结构，转录因子网络和表观遗传特征的差异。接下来，我们讨论与异常胎盘有关的妊娠并发症。最后，我们介绍了新兴的体外模型来研究人类胎盘，包括人滋养层干细胞（TS），滋养层和子宫内膜类器官，和人工胚胎。胎盘的结构和发育在人类和小鼠之间有很大的不同。最近建立的人TS细胞和滋养层和子宫内膜类器官增强了我们对人类胎盘发育机制的理解。这些体外模型将极大地推进我们对人类胎盘发育的理解，并可能有助于阐明不孕症和其他妊娠并发症的原因。
The placenta is an essential organ for the normal development of mammalian fetuses. Most of our knowledge on the molecular mechanisms of placental development has come from the analyses of mice, especially histopathological examination of knockout mice. Choriocarcinoma and immortalized cell lines have also been used for basic research on the human placenta. However, these cells are quite different from normal trophoblast cells. In this review, we first provide an overview of mouse and human placental development with particular focus on the differences in the anatomy, transcription factor networks, and epigenetic characteristics between these species. Next, we discuss pregnancy complications associated with abnormal placentation. Finally, we introduce emerging in vitro models to study the human placenta, including human trophoblast stem (TS) cells, trophoblast and endometrium organoids, and artificial embryos. The placental structure and development differ greatly between humans and mice. The recent establishment of human TS cells and trophoblast and endometrial organoids enhances our understanding of the mechanisms underlying human placental development. These in vitro models will greatly advance our understanding of human placental development and potentially contribute to the elucidation of the causes of infertility and other pregnancy complications.
登录
查看更多内容
影响因子：
64.8
作者：
Dickinson ME;Flenniken AM;Ji X;Teboul L;Wong MD;White JK;Meehan TF;Weninger WJ;Westerberg H;Adissu H;Baker CN;Bower L;Brown JM;Caddle LB;Chiani F;Clary D;Cleak J;Daly MJ;Denegre JM;Doe B;Dolan ME;Edie SM;Fuchs H;Gailus-Durner V;Galli A;Gambadoro A;Gallegos J;Guo S;Horner NR;Hsu CW;Johnson SJ;Kalaga S;Keith LC;Lanoue L;Lawson TN;Lek M;Mark M;Marschall S;Mason J;McElwee ML;Newbigging S;Nutter LM;Peterson KA;Ramirez-Solis R;Rowland DJ;Ryder E;Samocha KE;Seavitt JR;Selloum M;Szoke-Kovacs Z;Tamura M;Trainor AG;Tudose I;Wakana S;Warren J;Wendling O;West DB;Wong L;Yoshiki A;International Mouse Phenotyping Consortium;Jackson Laboratory;Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS);Charles River Laboratories;MRC Harwell;Toronto Centre for Phenogenomics;Wellcome Trust Sanger Institute;RIKEN BioResource Center;MacArthur DG;Tocchini-Valentini GP;Gao X;Flicek P;Bradley A;Skarnes WC;Justice MJ;Parkinson HE;Moore M;Wells S;Braun RE;Svenson KL;de Angelis MH;Herault Y;Mohun T;Mallon AM;Henkelman RM;Brown SD;Adams DJ;Lloyd KC;McKerlie C;Beaudet AL;Bućan M;Murray SA
通讯作者：
Murray SA
DOI：
10.1073/pnas.1733908100
发表时间：
2003-08-19
影响因子：
11.1
作者：
Arai, T;Kasper, JS;DeCaprio, JA
通讯作者：
DeCaprio, JA
DOI：
10.1073/pnas.1303094110
发表时间：
2013-03-26
影响因子：
11.1
作者：
Amita, Mitsuyoshi;Adachi, Katsuyuki;Ezashi, Toshihiko
通讯作者：
Ezashi, Toshihiko
DOI：
10.1016/j.bbrc.2012.12.135
发表时间：
2013-02-08
影响因子：
3.1
作者：
Chen, Ying;Wang, Kai;Leach, Richard
通讯作者：
Leach, Richard
DOI：
10.1073/pnas.1112304108
发表时间：
2011-11-15
影响因子：
11.1
作者：
Dupressoir, Anne;Vernochet, Cecile;Heidmann, Thierry
通讯作者：
Heidmann, Thierry