Role of the long slender to short stumpy transition in the life cycle of the African trypanosomes.
Role of the long slender to short stumpy transition in the life cycle of the African trypanosomes.
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DOI：
10.1186/1475-9292-2-3
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发表时间：
2003-06-25
期刊：
影响因子：
--
通讯作者：
Wenck, Mary Anne
中科院分区：
文献类型：
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作者：
Seed, John Richard;Wenck, Mary Anne
使用小鼠模型表明，非洲锥虫对其宿主的碳水化合物（能量）资源产生显著的消耗;寄生虫血症越高，能量需求越大。因此，有人推测，长细长（LS）短树桩（SS）的过渡演变，部分，以帮助控制寄生虫血症，并增加主机的生存时间。还表明SS人群是异质的。一部分人群是采采蝇感染，而第二个老年SS人口正在经历类似寄生虫的事件，这导致他们的细胞死亡和刺激宿主的免疫反应。这种由老的垂死的SS形式产生的免疫刺激将消除主要的LS和SS变体抗原群体，并产生慢性复发性感染。它的结论是，SS阶段在类利他过程中的利他行为。它们献出自己的生命，以确保宿主的长期生存，并确保次要LS变体和新的感染性SS形式的重新生长。预计这一过程将增加锥虫成功传播到新宿主的可能性。
It is shown using mouse models that the African trypanosomes exert a significant drain upon their host's carbohydrate (energy) resources; and that the higher the parasitemia, the greater the energy demand. It is, therefore, hypothesized that the long slender (LS) to short stumpy (SS) transition evolved, in part, to help control the parasitemia and to increase host survival time. It is also suggested that the SS population is heterogeneous. One part of the population is tsetse infective, while a second older SS population is undergoing apoptotic-like events, which leads to their cell death and their stimulation of the host's immune response. This immune stimulation by the old dying SS forms would eliminate the major LS and SS variant antigen population, and produce the chronic relapsing infection. It is concluded that the SS stages during the apoptosis-like process are acting altruistically. They give their lives to insure the long-term survival of the host, and to insure renewed growth of the minor LS variants and new infective SS forms. This process is predicted to increase the probability for the successful transmission of the trypanosomes to a new host.