Recent advances and challenges in graphene-based nanocomposite scaffolds for tissue engineering application.
Recent advances and challenges in graphene-based nanocomposite scaffolds for tissue engineering application.
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DOI：
10.1002/jbm.a.37417
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发表时间：
2022-06
期刊：
影响因子：
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通讯作者：
Z. Niknam;Faezeh Hosseinzadeh;F. Shams;Leyla Fath-Bayati;Ghader Nuoroozi;Leila Mohammadi Amirabad;
中科院分区：
文献类型：
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作者：
Z. Niknam;Faezeh Hosseinzadeh;F. Shams;Leyla Fath-Bayati;Ghader Nuoroozi;Leila Mohammadi Amirabad;
石墨烯基纳米复合材料由于其独特的性能，近年来在组织工程领域引起了越来越多的关注。这些生物相容性物质，在适当的微环境存在下，可以刺激和维持干细胞的生长和分化成不同的谱系。本文综述了石墨烯及其衍生物的特性，如优异的电信号传导、载流子迁移率、优异的机械强度和表面特性、自润滑性、抗磨性、巨大的比表面积以及易于官能团修饰等。此外，石墨烯及其衍生物在生物相容性，毒性和与免疫细胞的相互作用方面的应用中的安全问题进行了讨论。我们还描述了石墨烯基纳米复合材料在组织愈合和器官再生中的适用性，特别是在骨、软骨、牙齿、神经元、心脏、骨骼肌和皮肤中。石墨烯基纳米材料的特殊纹理和结构特征对各种组织再生的影响被强调。最后，本综述给出了一些提示，对未来的研究，这些令人兴奋的材料在临床研究中的转化。
Graphene-based nanocomposites have recently attracted increasing attention in tissue engineering because of their extraordinary features. These biocompatible substances, in the presence of an apt microenvironment, can stimulate and sustain the growth and differentiation of stem cells into different lineages. This review discusses the characteristics of graphene and its derivatives, such as their excellent electrical signal transduction, carrier mobility, outstanding mechanical strength with improving surface characteristics, self-lubrication, antiwear properties, enormous specific surface area, and ease of functional group modification. Moreover, safety issues in the application of graphene and its derivatives in terms of biocompatibility, toxicity, and interaction with immune cells are discussed. We also describe the applicability of graphene-based nanocomposites in tissue healing and organ regeneration, particularly in the bone, cartilage, teeth, neurons, heart, skeletal muscle, and skin. The impacts of special textural and structural characteristics of graphene-based nanomaterials on the regeneration of various tissues are highlighted. Finally, the present review gives some hints on future research for the transformation of these exciting materials in clinical studies.