Effects of Rapid or Slow Body Weight Reduction on Intramuscular Protein Degradation Pathways During Equivalent Weight Loss on Rats
Effects of Rapid or Slow Body Weight Reduction on Intramuscular Protein Degradation Pathways During Equivalent Weight Loss on Rats
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DOI：
10.33549/physiolres.933502
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发表时间：
2017-01-01
影响因子：
2.1
通讯作者：
Terada, S.
中科院分区：
文献类型：
--
作者：
Nonaka, Y.;Urashima, S.;Terada, S.
本研究的目的是比较短期禁食引起的快速体重减轻与每日热量限制引起的缓慢但相当的体重减轻对肌肉蛋白质降解途径和肌肉蛋白质含量的影响。对雄性Fischer大鼠进行30%卡路里限制2周以缓慢降低体重（缓慢）或禁食3天以快速降低体重，降低的水平与缓慢组相当（快速）。缓慢组和快速组的最终体重比对照组低约15%（p
The purpose of this study was to compare the effects of short-term fasting-induced rapid weight loss with those of slower but equivalent body weight loss induced by daily calorie restriction on muscle protein degradation pathways and muscle protein content. Male Fischer rats were subjected to either 30 % calorie restriction for 2 weeks to slowly decrease body weight (Slow) or 3-day fasting to rapidly decrease body weight by a comparable level of that of the Slow group (Rapid). The final body weights were about 15 % lower in both the Slow and Rapid groups than in the Con group (p