Radical scavenging activity of tea catechins and their related compounds
Radical scavenging activity of tea catechins and their related compounds
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DOI：
10.1271/bbb.63.1621
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发表时间：
1999-09-01
影响因子：
1.6
通讯作者：
Hara, Y
中科院分区：
文献类型：
--
作者：
Nanjo, F;Mori, M;Hara, Y
表没食子儿茶素没食子酸酯是茶儿茶素中对超氧阴离子、羟基自由基和1，1-二苯基-2-苦基肼基自由基最有效的清除剂。研究了茶儿茶素及其糖苷对超氧阴离子的清除作用，结果表明，儿茶素的B环上至少含有一个邻位二羟基和3位上至少含有一个没食子酰基，这对保持其清除自由基的能力是很重要的。儿茶素的化学计量因子分别为：（+）-儿茶素和（-）-表儿茶素2，（-）-表没食子儿茶素5，（-）-表儿茶素没食子酸酯7，（-）-表没食子儿茶素没食子酸酯10。
(-)-Epigallocatechin gallate was found to be the most effective scavenger among tea catechins for the superoxide anion, hydroxyl radical, and 1,1-diphenyl-2-picrylhydrazyl radical. Examination of the scavenging effects of tea catechins and their glucosides on superoxide anion showed that the presence of at least an ortho-dihydroxyl group in the B ring and a galloyl moiety at the 3 position was important in maintaining the effectiveness of the radical scavenging ability. Stoichiometric factors of tea catechins were estimated to be 2 for (+)-catechin and (-)-epicatechin, 5 for (-)-epigallocatechin, 7 for (-)-epicatechin gallate, and 10 for (-)-epigallocatechin gallate.