Influence of posture on the serum concentration of calcium.
Influence of posture on the serum concentration of calcium.
复制标题
姿势对血清钙浓度的影响。
DOI：
10.1016/0026-0495(73)90049-8
复制
发表时间：
1973
期刊：
影响因子：
--
通讯作者：
Sandra Locke
中科院分区：
文献类型：
--
作者：
H. Husdan;H. Husdan;A. Rapoport;A. Rapoport;Sandra Locke;Sandra Locke
实验旨在研究体位变化对血清总钙、血浆离子钙、镁、蛋白结合钙、总蛋白、白蛋白和球蛋白浓度的影响。体位变化对血浆离子钙和血清镁无影响。其余所有成员的反应都是一致的，即从卧位到直立位时，他们的浓度显著上升。坐着或躺着时，它们的值在大约12小时后下降到最低水平，此后变化不大。在同一时间段，躺着获得的所有值都显著低于坐着获得的值。由于姿势的改变，钙和蛋白质浓度的变化可能分别高达正常范围的47%和71%。通过使用Dent，特别是Parfitt开发的蛋白质校正，这些差异大大减少了。血清总钙和总蛋白浓度存在性别差异，后者更为显著。钙的差异似乎是因为它的蛋白质结合成分的不同。很明显，在解释血清钙浓度时必须考虑体位的影响。没有认识到这种影响，无疑是导致不同工作者提出的血钙正常范围不同的原因之一。
Experiments were designed to study the effects of change in posture on the serum concentrations of total calcium, plasma ionic calcium, magnesium, protein-bound calcium, total protein, albumin, and globulin. Plasma ionic calcium and serum magnesium were not influenced by changes in posture. All the remaining constituents responded in a consistent manner, namely, on changing from the lying to the erect position, their concentrations rose significantly. On sitting or on lying down, their values fell reaching minimal levels after about 1 2 hr and showing little change thereafter. All the values attained on lying were significantly lower than those reached on sitting in the same time periods. Variations in the concentrations of calcium and protein due to alteration in posture could amount to as much as 47% and 71%, respectively, of their normal range spans. These variations were considerably reduced by the use of protein corrections developed by Dent and in particular by Parfitt. A sex difference was noted in the concentrations of both serum total calcium and total protein, more marked in the latter. The difference in calcium appears due to a difference in its protein-bound component. It is clear that the influence of posture must be considered when interpreting serum calcium concentrations. Failure to recognize this influence has undoubtedly contributed to the variations in the normal ranges of serum calcium proposed by different workers.