Zika Virus-Associated Birth Defects, Costa Rica, 2016-2018.

Zika Virus-Associated Birth Defects, Costa Rica, 2016-2018.
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DOI:
10.3201/eid2702.202047
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发表时间:
2021-03
影响因子:
11.8
通讯作者:
Soriano-Fallas A
Soriano-Fallas A
中科院分区:
医学2区
文献类型:
--
作者:
Benavides-Lara A;la Paz Barboza-Arguello M;González-Elizondo M;Hernández-deMezerville M;Brenes-Chacón H;Ramírez-Rojas M;Ramírez-Hernández C;Arjona-Ortegón N;Godfred-Cato S;Valencia D;Moore CA;Soriano-Fallas A

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加强出生缺陷监测增加了对病毒相关异常的识别,包括小头畸形。2016年1月在哥斯达黎加确认寨卡病毒感染后,加强了国家监测系统,以监测相关的出生缺陷。为了描述2016年3月至2018年3月期间活产婴儿中寨卡病毒爆发的特征,我们进行了描述性分析。寨卡病毒相关出生缺陷患病率为每10万活产15.3例。在22名患有寨卡病毒相关出生缺陷的婴儿中,11名被指定为确诊病例(寨卡病毒阳性),11名被指定为可能病例(寨卡病毒阴性或未接受检测,但母亲在怀孕期间接触过寨卡病毒)。共有91%的患者患有小头畸形(头围低于年龄和性别的平均值2sd), 64%的患者患有重度小头畸形(头围低于年龄和性别的平均值3sd), 95%的患者患有神经发育异常,82%的患者患有脑异常,41%的患者患有眼异常,9%的患者患有听力损失。除小头畸形外,监测儿童1 - 10岁可增加对寨卡病毒相关异常的识别。
Enhanced birth defect surveillance increased identification of virus-associated abnormalities, including microcephaly. After Zika virus (ZIKV) infection in Costa Rica was confirmed in January 2016, the national surveillance system was enhanced to monitor associated birth defects. To characterize the ZIKV outbreak among live-born infants during March 2016–March 2018, we conducted a descriptive analysis. Prevalence of ZIKV-associated birth defects was 15.3 cases/100,000 live births. Among 22 infants with ZIKV-associated birth defects, 11 were designated as confirmed (positive for ZIKV) and 11 were designated as probable cases (negative for ZIKV or not tested, but mother was expsed to ZIKV during pregnancy). A total of 91% had microcephaly (head circumference >2 SDs below mean for age and sex), 64% severe microcephaly (head circumference >3 SDs below mean for age and sex), 95% neurodevelopmental abnormalities, 82% brain anomalies, 41% eye abnormalities, and 9% hearing loss. Monitoring children for >1 year can increase identification of ZIKV-associated abnormalities in addition to microcephaly.
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发表时间: 2016-08-27
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