Effects of perfluorodecanoic acid on de novo fatty acid and cholesterol synthesis in the rat.
Effects of perfluorodecanoic acid on de novo fatty acid and cholesterol synthesis in the rat.
复制标题
全氟癸酸对大鼠从头脂肪酸和胆固醇合成的影响。
作者：
Davis2nd,JW;VandenHeuvel,JP;Peterson,RE
全氟癸酸（PFDA）是一种过氧化物酶体增殖剂，可导致大鼠肝脏三酰甘油和胆固醇酯水平呈剂量依赖性（20-80 mg/kg）增加。我们假设PFDA可能导致该物种脂肪酸和胆固醇的新生合成增加，这可以解释观察到的效应。在大鼠接受溶剂或20或80 mg/kg PFDA后7天检查3 H2O掺入组织脂质。PFDA处理降低了肝脏和附睾脂肪垫中胆固醇和脂肪酸的合成速率。在减少脂肪酸和胆固醇的新生合成的PFDA剂量（20 mg/kg）下，对肝脏、附睾脂肪垫和血浆中的脂肪酸和胆固醇浓度没有影响。我们的结论是，PFDA诱导的脂肪肝是由于在肝脏中的脂肪酸的氧化减少，或三酰甘油catalysts和/或从肝脏输出的损害，而不是增加的结果，脂肪酸和胆固醇的内源性合成。
Perfluorodecanoic acid (PFDA) is a peroxisome proliferator that causes a dose-dependent (20–80 mg/kg) increase in hepatic triacylglycerol and cholesteryl ester levels in the rat. We hypothesized that PFDA may cause an increase in thede novosynthesis of fatty acids and cholesterol in this species, which would explain observed effects. The incorporation of3H2O into tissue lipids was examined 7 days after rats received vehicle or 20 or 80 mg/kg of PFDA. PFDA treatment decreased the rate of synthesis of cholesterol and fatty acids in the liver and in epididymal fat pad. At a PFDA dose (20 mg/kg) that decreasedde novosynthesis of fatty acids and cholesterol, there was no effect on the concentration of fatty acids and cholesterol in the liver, epididymal fat pads, and plasma. We conclude that PFDA induced fatty liver is due to either a decrease in the oxidation of fatty acids in the liver, or an impairment of triacylglycerol catabolism and/or export from the liver, and is not the result of an increase inde novosynthesis of fatty acids and cholesterol.