The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling.
The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling.
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DOI：
10.3390/ijms18030608
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发表时间：
2017-03-10
影响因子：
5.6
通讯作者：
Li P
中科院分区：
文献类型：
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作者：
Gao J;Xu W;Wang J;Wang K;Li P
非编码 RNA (ncRNA) 是一类不编码蛋白质的 RNA 分子。研究表明，ncRNA不仅参与细胞增殖、凋亡、分化、代谢等生理过程，还参与疾病的发病机制。心脏重构是多种心血管疾病的主要病理基础。许多研究表明心脏重构的发生和发展与ncRNA的调控密切相关。近年来ncRNA在心脏病中的研究取得了快速发展。因此，我们在此总结了ncRNA，包括microRNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA）在心脏重塑中的最新研究进展，并重点阐述其分子机制，旨在寻找心脏病治疗的新靶点。
Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. Studies show that ncRNAs are not only involved in cell proliferation, apoptosis, differentiation, metabolism and other physiological processes, but also involved in the pathogenesis of diseases. Cardiac remodeling is the main pathological basis of a variety of cardiovascular diseases. Many studies have shown that the occurrence and development of cardiac remodeling are closely related with the regulation of ncRNAs. Recent research of ncRNAs in heart disease has achieved rapid development. Thus, we summarize here the latest research progress and mainly the molecular mechanism of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), in cardiac remodeling, aiming to look for new targets for heart disease treatment.