Congruence of BOLD response across intertemporal choice conditions: fictive and real money gains and losses.
Congruence of BOLD response across intertemporal choice conditions: fictive and real money gains and losses.
复制标题
DOI：
10.1523/jneurosci.5319-08.2009
复制
发表时间：
2009-07-08
期刊：
影响因子：
--
通讯作者：
Angtuaco EJ
中科院分区：
文献类型：
--
作者：
Bickel WK;Pitcock JA;Yi R;Angtuaco EJ
跨期选择是基于商品在收到之前的延迟估价。未来结果的主观价值会随着时间的推移而降低或打折。虽然行为研究表明，对真实的和虚构的结果的贬低之间没有区别，但没有神经成像研究调查潜在的审议过程中的潜在差异。在这里，我们比较行为和神经相关的跨期估值的真实的和假设的货币收益以及假设的损失，这已被假定为涉及不同的机制。进行了行为和神经成像会议，参与者在收益条件下使用真实的和假设的100美元，在损失条件下使用虚构的100美元做出跨期选择决策。行为数据的受试者内比较显示，在三种情况下，折扣水平之间没有显着差异。三个贴现条件的fMRI数据的随机效应分析独立地揭示了边缘系统（前扣带、纹状体、后扣带）和执行功能区（外侧前额叶皮层）的显著信号变化，而重复测量ANOVA在校正多重比较后未能检测到跨三个贴现条件的信号变化差异。这些数据支持延迟折扣研究的真实的和假设条件之间的一致性，并进一步表明与不同形式的跨时选择的慎思过程相关的大脑区域的fMRI BOLD信号的一致性。
Intertemporal choice is predicated on the valuation of commodities with respect to delay until their receipt. Subjective value of a future outcome decreases, or is discounted, as a function of that delay. While behavioral studies suggest no difference between the devaluation of real and fictive outcomes, no neuroimaging studies have investigated potential differences in the underlying deliberative process. Here we compare behavioral and neural correlates of intertemporal valuation of real and hypothetical monetary gains as well as hypothetical losses, which have been posited to involve different mechanisms. Behavioral and neuroimaging sessions were conducted in which participants made intertemporal choice decisions in a gains condition using both real and hypothetical $100 money, and in a loss condition using a fictive $100 money. Within-subject comparison of behavioral data revealed no significant difference between levels of discounting across the three conditions. Random-effects analysis of fMRI data of each of the three discounting conditions independently revealed significant signal change in limbic (anterior cingulate, striatum, posterior cingulate) and executive functioning areas (lateral pre-frontal cortex), while a repeated measures ANOVA failed to detect differences in signal change across the three discounting conditions after correcting for multiple comparisons. These data support a concordance between real and hypothetical conditions from delay discounting studies and further suggest a congruence of the fMRI BOLD signal across brain regions associated with the deliberative process of different forms of intertemporal choice.