Roles as metabolic regulators of the non nutrients, capsaicin and capsiate, supplemented to diets
Roles as metabolic regulators of the non nutrients, capsaicin and capsiate, supplemented to diets
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DOI：
10.2183/pjab.79b.207
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发表时间：
2003-09-01
影响因子：
3.1
通讯作者：
Watanabe, T
中科院分区：
文献类型：
--
作者：
Iwai, K;Yazawa, A;Watanabe, T
辣椒素是红辣椒的辛辣成分，是非营养素。在高脂肪饮食中添加辣椒素可以通过激活大鼠的肾上腺交感神经从肾上腺分泌肾上腺素来防止脂肪组织中的脂肪沉积。我们小组最近从辛辣品种中选择和固定的非辛辣红辣椒中发现的辣椒素类似物的化学结构是一种新型化合物辣椒酸。研究了辣椒素酯在大鼠口服后的胃肠道吸收和代谢情况。辣椒素迅速从胃肠道上部区域消失。它被裂解为香草醇和香草酸。裂解产物以葡萄糖醛酸等共轭复合物的形式从尿液中排出。研究了辣椒素对麻醉大鼠肾上腺髓质分泌肾上腺素的影响。辣椒素以剂量依赖性方式引起快速且短暂的肾上腺素分泌。 Capsazepine 是香草酸（辣椒素）受体亚型 1 (VR1) 的特异性抑制剂，可阻断辣椒素诱导的肾上腺素分泌，表明 VR1 参与了这种反应。这些结果表明，辣椒素和辣椒酸等非营养素可以很好地吸收到血液中，并在调节能量和脂质代谢中发挥重要作用。
Capsaicin is a pungent principle of hot red pepper and a non-nutrient. Capsaicin supplementation to high fat diet prevents fat deposit in the adipose tissue through secretion of adrenaline from the adrenal gland via activation of adrenal sympathetic nerve in rats. The chemical structure of a capsaicin analog found in non-pungent red pepper which was selected and fixed from a pungent variety was recently determined by our group to be a novel compound, capsiate. The gastrointestinal absorption and the metabolism of capsiate after oral administration in rats was studied. Capsiate rapidly disappeared from upper region of the gastrointestinal tract. It was cleaved to vanillyl alcohol and vanillic acid. The cleaved products were excreted in the urine as a conjugated complex such as glucuronide. The effect of capsiate on adrenaline secretion from the adrenal medulla of anesthetized rats was investigated. Capsiate evoked rapid and transient adrenaline secretion as dose-dependent manner. Capsazepine, a specific inhibitor of vanilloid (capsaicin) receptor subtype 1 (VR1), blocked capsiate-induced adrenaline secretion to show the participation of VR1 for this response. These results support that non-nutrients such as capsaicin and capsiate are well absorbed into blood and play important roles in regulating energy and lipid metabolism.