Incubation of cocaine craving after withdrawal: a review of preclinical data
Incubation of cocaine craving after withdrawal: a review of preclinical data
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DOI：
10.1016/j.neuropharm.2004.06.027
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发表时间：
2004-01-01
影响因子：
4.7
通讯作者：
Shaham, Y
中科院分区：
文献类型：
--
作者：
Lu, L;Grimm, JW;Shaham, Y
使用药物渴望和复发的大鼠模型，我们最近发现，在可卡因自我给药戒断后的前2个月内，重新暴露于药物相关线索诱导的可卡因寻求逐渐增加，这表明药物渴望随着时间的推移而潜伏[Nature 412（2001）141]。在这里，我们总结了进一步表征这种潜伏现象的研究数据，并简要讨论了其对药物成瘾的影响。我们正在进行的研究的主要发现是：1。可卡因渴望的潜伏期是长期的，但不是永久的：暴露于可卡因线索诱导的可卡因寻求在戒断后的3个月内仍然升高，但在6个月后下降。奖励渴望的孵化不是药物特异性的：蔗糖寻求诱导重新暴露于奖励线索也增加后撤回，但时间比可卡因短。在急性重新暴露于可卡因本身后，可卡因渴望的潜伏期并不明显：在戒断的前6个月内，由可卡因引发注射诱导的可卡因寻求基本上保持不变。戒断后可卡因渴求的潜伏期与中脑边缘多巴胺区脑源性神经营养因子（BDNF）水平的增加有关。爱思唯尔有限公司出版
Using a rat model of drug craving and relapse, we recently found that cocaine seeking induced by re-exposure to drug-associated cues progressively increases over the first 2 months after withdrawal from cocaine self-administration, suggesting that drug craving incubates over time [Nature 412 (2001) 141]. Here, we summarize data from studies that further characterized this incubation phenomenon and briefly discuss its implications for drug addiction. The main findings of our ongoing research are:1. Incubation of cocaine craving is long-lasting, but not permanent: cocaine seeking induced by exposure to cocaine cues remains elevated for up to 3 months of withdrawal, but decreases after 6 months.2. Incubation of reward craving is not drug specific: sucrose seeking induced by re-exposure to the reward cues also increases after withdrawal, but for a time period that is shorter than that of cocaine.3. Incubation of cocaine craving is not evident after acute re-exposure to cocaine itself: cocaine seeking induced by cocaine priming injections remains essentially unchanged over the first 6 months of withdrawal.4. Incubation of cocaine craving after withdrawal is associated with increases in the levels of brain-derived neurotrophic factor (BDNF) in meso-limbic dopamine areas. Published by Elsevier Ltd.