Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex
Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex
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DOI：
10.1016/j.neurobiolaging.2008.12.008
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发表时间：
2010-12-01
影响因子：
4.2
通讯作者：
Cohen, Leonardo G.
中科院分区：
文献类型：
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作者：
Hummel, Friedhelm C.;Heise, Kirstin;Cohen, Leonardo G.
健康老龄化伴随着日常生活活动和个人独立能力的限制。最近的报道表明，在年轻健康成人中，无创阳极直流电刺激（tDCS）对初级运动皮层（M1）诱导的运动功能改善。在这里，我们通过双盲交叉研究设计验证了这样一个假设：相对于Sham，老年受试者在左M1上进行单次无节点tDCS可以促进日常生活活动所需的右上肢任务的执行（捷成-泰勒手功能测试，JTT）。我们发现(a)与假手术相比，tDCS对JTT功能的显著改善至少持续了30分钟，(b)受试者年龄越大，这种改善越明显，(c)与之前在年轻受试者中的结果一致，这些效果没有伴随着任何明显的不良副作用。我们的结论是，在M1上应用阳极tDCS可以促进老年受试者日常生活活动所需的熟练手功能的表现。(C) 2008爱思唯尔公司版权所有。
Healthy ageing is accompanied by limitations in performance of activities of daily living and personal independence. Recent reports demonstrated improvements in motor function induced by noninvasive anodal direct current stimulation (tDCS) of the primary motor cortex (M1) in young healthy adults. Here we tested the hypothesis that a single session of anodal tDCS over left M1 could facilitate performance of right upper extremity tasks required for activities of daily living (Jebsen-Taylor hand function test, JTT) in older subjects relative to Sham in a double-blind cross-over study design. We found (a) significant improvement in JTT function with tDCS relative to Sham that outlasted the stimulation period by at least 30 min, (b) that the older the subjects the more prominent this improvement appeared and (c) that consistent with previous results in younger subjects, these effects were not accompanied by any overt undesired side effect. We conclude that anodal tDCS applied over M1 can facilitate performance of skilled hand functions required for activities of daily living in older subjects. (C) 2008 Elsevier Inc. All rights reserved.