Plasma neutrophil gelatinase-associated lipocalin as a biomarker for acute kidney injury in critically ill patients with suspected sepsis
Plasma neutrophil gelatinase-associated lipocalin as a biomarker for acute kidney injury in critically ill patients with suspected sepsis
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DOI：
10.1016/j.clinbiochem.2013.05.069
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发表时间：
2013-10-01
影响因子：
2.8
通讯作者：
Yun, Yeo-Min
中科院分区：
文献类型：
--
作者：
Kim, Hanah;Hur, Mina;Yun, Yeo-Min
目的：本研究旨在探讨血浆中性粒细胞明胶酶相关脂蛋白(NGAL)作为早期客观生物标志物预测疑似脓毒症危重患者急性肾损伤(AKI)的价值，并应用降钙素原(PCT)对其进行诊断和分期。设计与方法：采用美国加利福尼亚州圣迭戈Alere公司的Triage NGAL试验检测231例疑似败血症患者的血浆NGAL。NGAL的结果与Electrsys Brahms PCT(罗氏诊断公司，瑞士巴塞尔)的结果进行了比较。肾功能衰竭采用脓毒症相关器官衰竭评估(SOFA)中的肾功能亚分进行评估。结果：5组患者血浆NGAL浓度差异有统计学意义(P<；0.0001)，肾功能评分差异有统计学意义(P<；0.0001)。急性肾功能衰竭患者血浆神经生长因子水平明显高于非急性肾功能衰竭患者(416.5 ng/mLvs.181.0 ng/mI，P=0.0223)。结论：血浆神经生长因子可作为脓毒症患者急性肾功能衰竭的一个高度敏感和客观的预测指标。血浆NGAL可用于脓毒症肾功能衰竭的诊断和分期。(C)2013年加拿大临床化学家学会。爱思唯尔公司出版，版权所有。
Objectives: The aim of this study was to investigate the diagnostic utility of plasma neutrophil gelatinase-associated lipocalin (NGAL) as an early objective biomarker to predict acute kidney injury (AKI) in critically ill patients with suspected sepsis, for whom procalcitonin (PCT) was used for the diagnosis and staging of sepsis.Design and methods: Plasma NGAL was measured using the Triage NGAL Test (Alere, Inc., San Diego, CA, USA) in 231 samples obtained from patients with suspected sepsis. The results of NGAL were compared with those of Elecsys BRAHMS PCT (Roche Diagnostics, Basel, Switzerland). Renal failure was assessed using the renal subscore of Sepsis-related Organ Failure Assessment (SOFA) score. AKI was defined according to the Acute Kidney Injury Network criteria.Results: The concentrations of plasma NGAL were significantly different according to the five groups of PCT concentration (P < 0.0001) and the renal subscore of SOFA score ( P < 0.0001). Plasma NGAL was significantly increased in the patients with AKI compared with those without AKI (416.5 ng/mL vs. 181.0 ng/mI, P = 0.0223).Conclusion: Plasma NGAL seems to be a highly sensitive and objective predictor of AKI in patients with sepsis. Plasma NGAL can be added for the diagnosis and staging of renal failure in sepsis. (c) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.