The effects of tamoxifen on radiation-induced pulmonary fibrosis in Wistar albino rats: Results of an experimental study
The effects of tamoxifen on radiation-induced pulmonary fibrosis in Wistar albino rats: Results of an experimental study
复制标题
DOI：
10.1016/j.breast.2005.04.016
复制
发表时间：
2006-06-01
期刊：
影响因子：
3.9
通讯作者：
Ober, Ahmet
中科院分区：
文献类型：
--
作者：
Bese, Nuran Senel;Umay, Cenk;Ober, Ahmet
本研究旨在评估他莫昔芬对Wistar白化大鼠肺纤维化的影响，同时给予或照射后给予。雌性Wistar白化大鼠21只，随机分为3组。第一组（A组）给予他莫昔芬，在照射结束后开始给药。第二组（B组）在放射治疗的同时给予他莫昔芬。第三组（C组）只进行胸部照射，不给予他莫昔芬。用Co60对全肺进行10次照射，总剂量为30gy。他莫昔芬持续使用，直到动物在照射开始16周后被处死。作为终点，通过对肺组织切片的图像分析，对每只大鼠的肺纤维化百分比进行量化。各组间比较采用单因素方差分析方法和Bonferroni事后检验。A组、B组和C组的平均纤维化百分比分别为10.03、36.81和3.87 （P < 0.001）。比较各组间纤维化百分比，A组与B组、B组与C组间差异均有统计学意义（P < 0.001）。同时使用他莫昔芬似乎会增加辐射诱导的肺纤维化，延迟他莫昔芬治疗至放疗完成似乎更为方便。(C) 2005 Elsevier Ltd版权所有。
This study was performed to evaluate the effects of tamoxifen on pulmonary fibrosis, given concurrently with or after irradiation in Wistar albino rats. Twenty-one female Wistar albino rats were randomized into three groups. The first group (Group A) had tamoxifen, which was started after the completion of irradiation. The second group (Group B) had tamoxifen concomitant with irradiation. The third group (Group C) had only thoracic irradiation and did not receive tamoxifen. Whole lungs were irradiated to a total dose of 30 Gy in ten fractions with Co60. Tamoxifen was continued until the animals were sacrificed 16 weeks after the start of irradiation. As an end point the percentage of lung with fibrosis for each rat was quantified with image analysis of histological sections of the lung. Groups were compared using the one-way ANOVA method and Bonferroni post hoc test. The mean percentage values of fibrosis were 10.03 for Group A, 36.81 for Group B, and 3.87 for group C (P < 0.001). When the percentages of fibrosis were compared for each group, the difference was statistically significant between Group A and Group B (P < 0.001) and between Group B and Group C (P < 0.001). Concomitant use of tamoxifen appears to increase radiation-induced pulmonary fibrosis and it seems more convenient to delay tamoxifen until the completion of irradiation. (C) 2005 Elsevier Ltd. All rights reserved.