Injectable Adhesive Self-Healing Multiple-Dynamic-Bond Crosslinked Hydrogel with Photothermal Antibacterial Activity for Infected Wound Healing
Injectable Adhesive Self-Healing Multiple-Dynamic-Bond Crosslinked Hydrogel with Photothermal Antibacterial Activity for Infected Wound Healing
复制标题
具有光热抗菌活性的可注射粘合剂自愈多重动力键交联水凝胶，可促进感染伤口愈合
DOI：
10.1021/acs.chemmater.1c03944
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发表时间：
2022-03-22
影响因子：
8.6
通讯作者：
Xue, Wei
中科院分区：
文献类型：
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作者：
Guo, Huilong;Huang, Shan;Xue, Wei
在实际应用中，强烈建议开发具有自我愈合能力、形状适应性、按需可拆卸性和优异的光热抗菌活性的多功能可注射性粘附性水凝胶，以促进细菌感染的伤口愈合。在本工作中，通过动态的硼酸盐/二醇相互作用、氢键和席夫碱键的多重动态键交联网，形成了一种可注射的粘合剂自愈合多动态键交联水凝胶。在水凝胶中引入贻贝类邻苯二酚基团可以赋予组织粘附性，水凝胶在水中能很好地附着在皮肤上，在弯曲和扭曲状态下具有良好的形状适应性。在动态席夫碱交联的邻苯二酚改性水凝胶中引入了硼酸盐/二醇相互作用，提高了其力学性能和粘接性能，且成本低、制备简单，且粘接水凝胶可在不对伤口造成二次损伤的情况下去除。此外，聚多巴胺纳米粒子(PDA NPs)通过聚多巴胺纳米粒子表面的苯醌基团与乙二醇壳聚糖(GC)中伯胺的席夫碱反应引入到水凝胶中，使PDA纳米粒子均匀分散在水凝胶中，具有高效的光热抗菌活性。水凝胶具有良好的细胞相容性和血液相容性。最后，它们可以被注射来完全填充不规则的伤口，并通过减少炎症反应，加速胶原沉积，促进血管重建，显著促进细菌感染的伤口愈合。因此，这表明了它们作为治疗细菌感染伤口的多功能敷料的优越性。
The development of multifunctional injectable adhesive hydrogels with self-healing capacity, shape adaptability, on-demand removability, and excellent photothermal antibacterial activity to promote bacteria-infected wound healing is highly recommended in practical applications. In this work, an injectable adhesive self-healing multiple-dynamic-bond crosslinked hydrogel was formed by a multiple-dynamic-bond crosslinked network of dynamic borate/didiol interactions, hydrogen bonding, and Schiff base bond. The introduction of Mussel-inspired catechol groups into the hydrogels could endow tissues with adhesive properties, and the hydrogel could adhere well to the skin under water with good shape adaptability under bent and twisted states. The mechanical and adhesive properties improved through the introduction of borate/didiol interactions into the catechol-modified hydrogel with dynamic Schiff base crosslinking at low cost and easy preparation, and the adhesive hydrogel could be removed without second damage to the wound. Moreover, polydopamine nanoparticles (PDA NPs) were introduced into the hydrogels through Schiff base reactions between the quinone group on PDA NPs and the primary amine in glycol chitosan (GC), resulting in an efficient photothermal antibacterial activity with uniformly dispersed PDA NPs in the hydrogel. And the hydrogels illustrated good cytocompatibility and hemocompatibility. Finally, they could be injected to fully fill irregular wounds and significantly promote bacteria-infected wound healing by reducing the inflammatory response, accelerating collagen deposition, and promoting blood vessel reconstruction. Therefore, this demonstrated their superiority in serving as multifunctional dressings for treating a bacteria-infected wound.