Signaling organelles of the innate immune system.
Signaling organelles of the innate immune system.
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DOI：
10.1016/j.cell.2012.11.011
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发表时间：
2012-12-07
期刊：
影响因子：
64.5
通讯作者：
Kagan JC
中科院分区：
文献类型：
--
作者：
Kagan JC
至少有五个家族的微生物检测受体，其功能是检测和根除进入多细胞真核生物的潜在感染性微生物。虽然已经确定了许多调节先天免疫信号转导的蛋白质，但对先天免疫调节剂的连续遗传筛选可能不会像过去那样对这些途径的运作产生显著的洞察力。这种实验投资回报的减少表明，我们正在接近研究先天免疫的遗传学方法的渐近线。相比之下，尚不清楚已知的先天免疫调节剂如何在哺乳动物细胞的基础结构内相互作用以执行其信号功能。在这个角度来看，我首先强调哺乳动物细胞内的位置，允许先天免疫信号转导，然后提供一个模型，使结构上不同的蛋白质可以分组功能，通过他们的能力，组装平台上的先天免疫系统的信号细胞器的监管机构。
There are at least five families of microbe-detection receptors that function to detect and eradicate potentially infectious microorganisms that enter multicellular eukaryotes. While a multitude of proteins regulating innate immune signal transduction have already been defined, continuous genetic screening for regulators of innate immunity may not yield as significant insight into the operation of these pathways as was obtained in the past. This diminished return on experimental investment suggests that we are approaching the asymptote of genetics-only approaches to study innate immunity. In contrast, it remains unclear how known regulators of innate immunity interact within the infrastructure of mammalian cells to execute their signaling functions. In this Perspective, I first highlight the locations within mammalian cells that permit innate immune signal transduction and then offer a model whereby structurally distinct proteins can be grouped functionally through their ability to assemble platforms of regulators on the signaling organelles of the innate immune system.
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DOI：
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发表时间：
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期刊：
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影响因子：
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