Haemopoietic mechanisms in nasal polyposis and asthma
Haemopoietic mechanisms in nasal polyposis and asthma
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DOI：
10.1136/thorax.55.suppl_2.s24
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发表时间：
2000-10-01
期刊：
影响因子：
10
通讯作者：
Denburg, JA
中科院分区：
文献类型：
--
作者：
Denburg, JA
ConclusionThe studies outlined above indicate that several anti-allergic agents have diVerential eVects in regulating the expression of IL-5Rα and of eosinophil progenitors in several models of allergic airways disease. The functional consequence in vitro and in vivo of this regulatory eVect on IL-5Rα is a modulation of eosinophil/basophil diVerentiation. Thus, the therapeutic benefit of agents such as corticosteroids, leukotriene antagonists, and retinoids in allergic airways inflammation may be dependent upon the degree to which eosinophil diVerentiation is modulated.
