Antifungal cobalt(II), copper(II), nickel(II) and zinc(II) complexes of furanyl-, thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-derived cephalexins
Antifungal cobalt(II), copper(II), nickel(II) and zinc(II) complexes of furanyl-, thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-derived cephalexins
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DOI：
10.1080/14756360310001650183
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发表时间：
2004-02-01
影响因子：
5.6
通讯作者：
Supuran, CT
中科院分区：
文献类型：
--
作者：
Chohan, ZH;Pervez, H;Supuran, CT
合成了几种头孢菌素衍生的呋喃基、噻吩基、吡咯基、水杨基和吡啶基席夫碱及其钴（II）、铜（II）、镍（II）和锌（II）配合物，并研究了它们对长梭毛癣菌、白色念珠菌、黄曲霉、犬小孢子菌、茄病镰刀菌和光滑念珠菌的抗真菌活性。金属离子的存在下，在这里报道的研究席夫碱配合物导致显着的抗真菌活性，而母体配体一般活性较低。
Some novel cephalexin-derived furanyl, thiophenyl, pyrrolyl, salicylyl and pyridyl Schiff's bases and their cobalt (II), copper (II), nickel (II) and zinc (II) complexes have been synthesized and studied for their antifungal properties against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata. The presence of metal ions in the investigated Schiff's base complexes reported here lead to significant antifungal activity, whereas the parent ligands were generally less active.