Interaction between Nitrous Oxide and Diazepam in the Mouse Staircase Test
Interaction between Nitrous Oxide and Diazepam in the Mouse Staircase Test
复制标题
小鼠阶梯试验中一氧化二氮和地西泮的相互作用
作者：
R. J. Pruhs;R. Quock
在小鼠阶梯试验中评估氧化亚氮与地西泮的相互作用。在该范式中，后肢数（NR）（同时用后腿站立和嗅空气）和上升步数（NSA）分别反映了焦虑和运动活动。抗焦虑药物的特点是降低NR，但不降低NSA，而镇静药物的特点是同时降低NR和NSA。在这项研究中，仅增加一氧化二氮的浓度就会逐渐产生更大的、具有统计学意义的NSA增加。单独使用氧化亚氮对NR没有显著影响，直到浓度达到75%时，它才降低NR。单独使用地西泮在所有剂量下都同样显著地降低NR。在一定的浓度和剂量组合下，氧化亚氮增强了地西泮对NR的作用，但不改变NSA。这些发现表明，在小鼠阶梯模型中，氧化亚氮可以增加地西泮的抗焦虑作用，而不增加其镇静作用。
The interaction between nitrous oxide and diazepam was assessed in the mouse staircase test. In this paradigm, the numbers of rears (NR) (simultaneous standing on hindlegs and sniffing the air) and steps ascended (NSA) reflect anxiety and locomotor activity, respectively. Antianxiety drugs characteristically reduce NR but not NSA, while sedative drugs reduce both NR and NSA in generally parallel fashion. In this study, increasing concentrations of nitrous oxide alone produced progressively greater and statistically significant increases in NSA. Nitrous oxide alone had no significant effect on NR until, at a concentration of 75%, it decreased NR. Diazepam alone decreased NR equally and significantly at all doses. With certain combinations of concentration and dose, nitrous oxide enhanced the effect of diazepam on NR without altering NSA. These findings suggest that nitrous oxide can increase the antianxiety effect of diazepam without increasing its sedative effect in the mouse staircase paradigm.
一氧化二氮的镇痛作用与受控的疼痛刺激。
DOI：
10.14219/jada.archive.1983.0303
发表时间：
1983
期刊：
Journal of the American Dental Association (1939)
影响因子：
--
作者：
Dworkin,SF;Chen,AC;Schubert,MM;Clark,DW
通讯作者：
Clark,DW