Rhomboid-like proteins in apicomplexa: phylogeny and nomenclature
Rhomboid-like proteins in apicomplexa: phylogeny and nomenclature
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DOI：
10.1016/j.pt.2005.04.009
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发表时间：
2005-06-01
影响因子：
9.6
通讯作者：
Soldati, D
中科院分区：
文献类型：
--
作者：
Dowse, TJ;Soldati, D
菱形蛋白家族是一类多次跨膜丝氨酸蛋白酶。在刚地弓形虫中，一种被称为微线体蛋白蛋白酶1（MPP1）的关键活性在其跨膜结构域内切割分泌的黏附蛋白，切割位点在其他顶复门生物的相似蛋白中是保守的。目前的证据表明，MPP1在该门生物中普遍存在，并且由一个菱形蛋白基因编码。在本文中，我们基于系统发育分析的命名法，介绍了顶复门生物中目前已知的类菱形蛋白。
Rhomboids form a family of polytopic intramembrane serine proteases. In Toxoplasma gondii, an essential activity called microneme protein protease 1 (MPP1) cleaves secreted adhesive proteins within their transmembrane domains, at a site conserved in similar proteins of other Apicomplexa. Current evidence suggests that MPP1 is ubiquitous in the phylum and is encoded by a rhomboid gene. In this article, we present the current repertoire of rhomboid-like proteins in Apicomplexa using a nomenclature based on phylogenetic analyses.