The effect of metabolic syndrome components on exercise performance in patients with intermittent claudication
The effect of metabolic syndrome components on exercise performance in patients with intermittent claudication
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DOI：
10.1016/j.jvs.2008.01.048
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发表时间：
2008-06-01
影响因子：
4.3
通讯作者：
Montgomery, Polly S.
中科院分区：
文献类型：
--
作者：
Gardner, Andrew W.;Montgomery, Polly S.
目的：探讨代谢综合征各成分对外周动脉疾病(PAD)患者间歇性跛行、身体功能、健康相关生活质量和外周循环的影响，并找出对每种预后指标最具预测性的代谢综合征成分。在血管闭塞3分钟后对患者进行PAD特异性测量，包括踝臂指数(ABI)、初始跛行距离、绝对跛行距离、身体功能测量、与健康相关的生活质量、小腿血流和经皮氧分压反应。结果：在具有3个(203 167 M)、4个(124 77 M)和5个(78 57 M)代谢综合征成分的患者中，初始跛行距离(平均+/-SD)逐渐减少(P=0.019)，绝对跛行距离也逐渐减少(P=0.036)(分别为414 224 m和153 323 m对249 152 m)。此外，与仅有三种代谢综合征成分的患者相比，所有五种成分的代谢综合征患者均有不同程度的减分值(P
Purpose: To determine the effect of metabolic syndrome components on intermittent claudication, physical function, health-related quality of life, and peripheral circulation in patients with peripheral arterial disease (PAD), and to identify the metabolic syndrome components most predictive of each outcome measure.Methods: Patients limited by intermittent claudication with three (n = 48), four (n = 45), or five (n = 40) components of metabolic syndrome were studied. Patients were assessed on PAD-specific measures consisting of ankle-brachial index (ABI), initial claudication distance, absolute claudication distance, physical function measures, health-related quality of life, and calf blood flow and transcutaneous oxygen tension responses after 3 minutes of vascular occlusion.Results: Initial claudication distance (mean +/- SD) progressively declined (P=.019) in those with three (203 167 m), four (124 77 m), and five (78 57 m) metabolic syndrome components, and absolute claudication distance progressively declined (P=.036) in these groups as well (414 224 m vs 323 153 m vs 249 152 m, respectively). Furthermore, compared with patients with only three components of metabolic syndrome, those with all five components had impaired values (P