Brain-derived neurotrophic factor and nerve growth factor concentrations in maternal and umbilical cord blood of opium-addicted mothers
Brain-derived neurotrophic factor and nerve growth factor concentrations in maternal and umbilical cord blood of opium-addicted mothers
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DOI：
10.1002/jdn.10055
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发表时间：
2020-08-24
影响因子：
1.8
通讯作者：
Bornavard, Morad
中科院分区：
文献类型：
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作者：
Fanaei, Hamed;Riki, Farideh;Bornavard, Morad
据报道，怀孕期间吸食鸦片与不良妊娠结局和婴儿神经发育缺陷有关。怀孕期间BDNF和NGF的改变会导致后代的神经行为缺陷。本研究旨在探讨孕妇鸦片成瘾对母体和脐带血BDNF和NGF水平以及妊娠结局的影响。材料与方法本研究为横断面研究。35名吸毒孕妇和35名健康孕妇参与了这项研究。分娩后立即从母体静脉和脐带采集血样。采用ELISA试剂盒检测血清BDNF和NGF浓度。妊娠结局由检查表确定。采用描述性检验、ttest、Mann-Whitney检验和卡方检验对数据进行分析。采用SPSS 21版软件进行分析。与对照组（1351 +/- 375和1063 +/- 341 pg/ml）相比，鸦片成瘾组母血和脐带血ap值BDNF水平显著降低（分别为917.2 31 +/- 316.5和784.6 +/- 242.9 pg/ml） （p < 0.0002）。同样，鸦片成瘾组母血和脐带血NGF水平（分别为302.7 +/- 35.50和226.6 +/- 45.43 pg/ml）明显低于对照组（分别为345.7 +/- 43.16和251.2 +/- 37.72 pg/ml） （p = 0.0165）。不良妊娠结局，如新生儿重症监护病房入院、先天性异常、新生儿死亡、胎粪污染羊水、呼吸问题、新生儿复苏和低Apgar评分，鸦片成瘾组明显高于对照组。结论妊娠期吸食鸦片可降低母体和脐带血BDNF和NGF水平，可能导致婴儿后期神经发育障碍。
Background It is reported that opium consumption during pregnancy is associated with adverse pregnancy outcomes and neurodevelopmental defects in infants. BDNF and NGF alterations during pregnancy cause neurobehavioral deficits in the offspring. The aim of this study was to investigate the effect of opium addiction of pregnant women on BDNF and NGF levels in maternal and umbilical cord blood as well as pregnancy outcome. Materials and methods The present research was a cross-sectional study. Thirty-five addicted pregnant women and 35 healthy pregnant women were included in the study. Blood samples were taken immediately after delivery from the maternal vein and umbilical cord. Then, BDNF and NGF concentrations in serum were measured by ELISA kits. The outcomes of pregnancy were determined by a checklist. Descriptive,ttest, Mann-Whitney, and Chi-squared test were used to analyze the data. SPSS version 21 software was used for the analyses. Ap-value BDNF levels were significantly lower in maternal and umbilical cord blood in the opium-addicted group (917.2 31 +/- 316.5 and 784.6 +/- 242.9 pg/ml, respectively) compared to the control group (1351 +/- 375 and 1063 +/- 341 pg/ml, respectively) (p p < .0002, respectively). Similarly, NGF level was significantly lower in maternal and umbilical cord blood in the opium-addicted group (302.7 +/- 35.50 and 226.6 +/- 45.43 pg/ml, respectively) compared to the control group (345.7 +/- 43.16 and 251.2 +/- 37.72 pg/ml, respectively) (p p = .0165, respectively). Adverse pregnancy outcomes such as NICU admissions, congenital anomalies, neonatal deaths, meconium contaminated amniotic fluid, respiratory problems, neonatal resuscitation, and low Apgar score were significantly higher in the opium-addicted group than in the control group. Conclusion The results of this study revealed that opium consumption during pregnancy reduces BDNF and NGF levels in maternal and umbilical cord blood, which may cause neurodevelopmental disorders in later periods of infants' life.