A model for intracellular energy transport.
A model for intracellular energy transport.
复制标题
细胞内能量运输模型。
DOI：
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发表时间：
1982
影响因子：
2.1
通讯作者：
K. Rakušan
中科院分区：
文献类型：
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作者：
G. W. Mainwood;K. Rakušan
氧从毛细血管转移到细胞的模型被认为是在其中线粒体要么聚集在细胞周围的毛细血管或均匀地分布在胞质溶胶。当线粒体聚集在毛细血管周围时，以相同速率供应利用氧气的细胞所需的毛细血管Po 2要少得多。考虑了两种替代机制用于将能量从外周线粒体分配到细胞的其余部分;即，ATP或磷酸肌酸与足够的肌酸激酶的扩散，以确保近似P载体之间的平衡。后者具有明显的优点，并且似乎足以提供相当大的无氧化铝的电池芯（例如，24-微米直径），在最大工作速率下ADP水平或ATP水解的自由能变化很小。因此，提出了传统Krogh模型的可行替代方案，该模型考虑了线粒体聚集导致的扩散途径的不均匀性。
A model for oxygen transfer to cells from capillaries is considered in which mitochondria are either clustered at the cell periphery around capillaries or homogeneously distributed through the cytosol. The capillary Po2 required to supply cells utilizing oxygen at the same rate is much less when mitochondria cluster around capillaries. Two alternative mechanisms are considered for distributing energy from peripheral mitochondria to the rest of the cell; i.e., diffusion of ATP or creatine phosphate with enough creatine kinase to ensure equilibrium between the approximately P carriers. The latter has clear advantages and would appear to be adequate to supply a fairly large mitochondria-free cell core (e.g., 24-micrometer diameter) with very little change in ADP levels or in the free energy of ATP hydrolysis at maximum work rates. Thus, a viable alternative to the traditional Krogh model is presented which takes into account the inhomogeneity of the diffusion pathway as a result of mitochondrial clustering.