Sources of absorption and scattering contrast for near-infrared optical mammography
Sources of absorption and scattering contrast for near-infrared optical mammography
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DOI：
10.1016/s1076-6332(03)80529-9
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发表时间：
2001-03-01
影响因子：
4.8
通讯作者：
Tromberg, BJ
中科院分区：
文献类型：
--
作者：
Cerussi, AE;Berger, AJ;Tromberg, BJ
基本原理和目标。近红外 (NIR) 漫反射光谱和成像可以增强现有的乳腺癌筛查、诊断和治疗技术，NIR 技术基于健康组织和患病组织之间功能对比的灵敏、定量测量。在这项研究中，作者量化了健康乳房中这种对比的起源。材料和方法。使用七波长频域光子迁移探针对 28 名年龄在 18-64 岁的绝经前和绝经后健康女性的乳房进行无创近红外测量。光传输的扩散模型通过吸收特征来量化含氧和脱氧血红蛋白、水和脂质。测量的光散射光谱的变化通过“散射功率”参数进行量化。结果。作为受试者年龄的函数，在乳房的吸收和散射光谱中观察到显着的定量差异。这些生理变化与乳房中发生的长期激素依赖性转变一致。仪器响应不受受试者年龄或绝经状态的不利影响。结论。这些测量为内源性光学吸收和散射对比机制提供了新的见解，并对光学乳腺X线摄影的发展具有重要意义。近红外光谱可产生其他非侵入性放射技术无法获得的定量功能信息。
Rationale and Objectives. Near-infrared (NIR) diffuse optical spectroscopy and imaging may enhance existing technologies for breast cancer screening, diagnosis, and treatment, NIR techniques are based on sensitive, quantitative measurements of functional contrast between healthy and diseased tissue. In this study, the authors quantified the origins of this contrast in healthy breasts.Materials and Methods. A seven-wavelength frequency-domain photon migration probe was used to perform noninvasive NIR measurements in the breasts of 28 healthy women, both pre- and postmenopausal, aged 18-64 years. A diffusive model of light transport quantified oxygenated and deoxygenated hemoglobin, water, and lipid by their absorption signatures. Changes in the measured light-scattering spectra were quantified by means of a "scatter power" parameter.Results. Substantial quantitative differences were observed in both absorption and scattering spectra of breast as a function of subject age. These physiologic changes were consistent with long-term hormone-dependent transformations that occur in breast. Instrument response was not adversely affected by subject age or menopausal status.Conclusion. These measurements provide new insight into endogenous optical absorption and scattering contrast mechanisms and have important implications for the development of optical mammography. NIR spectroscopy yields quantitative functional information that cannot be obtained with other noninvasive radiologic techniques.