Neurotoxicity of aluminum and its link to neurodegenerative diseases
Neurotoxicity of aluminum and its link to neurodegenerative diseases
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铝的神经毒性及其与神经退行性疾病的联系
DOI：
10.11299/metallomicsresearch.mr202104
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Midori Kato-Negishi
中科院分区：
文献类型：
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作者：
Masahiro Kawahara;Ken-ichiro Tanaka; Midori Kato-Negishi
铝（Al）是地壳中第三丰富的元素。然而，由于其特殊的化学性质，人工智能并不是生命所必需的，它对植物、动物和人类都有各种不利影响。特别是，人工智能是一种被广泛认可的神经毒素。人们怀疑人工智能与Kii半岛和关岛的阿尔茨海默病、肌萎缩侧索硬化症和帕金森病痴呆等神经退行性疾病之间存在关联。然而，争论持续了几十年。基于最近的流行病学、分析和毒理学研究，我们回顾了Al神经毒性的详细特征，并重新审视其与阿尔茨海默病和其他疾病的联系。还描述了每日铝的摄入量及其与人体健康不利影响有关的生物利用度。
Aluminum (Al) is the third most abundant element in the earth’s crust. However, because of its specific chemical properties, Al is not essential for life, and it exerts various adverse effects on plants, animals, and humans. In particular, Al is a widely recognized neurotoxin. The association between Al and neurodegenerative diseases including Alzheimer’s disease, amyotrophic lateral sclerosis and Parkinson’s disease dementia in the Kii Peninsula and Guam has been suspected. However, controversy has persisted for several decades. Based on recent epidemiological, analytical, and toxicological studies, we review the detailed characteristics of Al neurotoxicity and revisit its link to Alzheimer’s disease and other diseases. The daily intake of Al and its bioavailability linked with adverse effects on human health are also described.