T lymphocyte subset changes in human immunodeficiency virus infection.
T lymphocyte subset changes in human immunodeficiency virus infection.
复制标题
人类免疫缺陷病毒感染中 T 淋巴细胞亚群的变化。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
E. Thorsby
中科院分区：
文献类型：
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作者：
J. Brinchmann;F. Vartdal;E. Thorsby
The absolute number of CD4+ and CD8+ T cells was determined by an immunomagnetic technique directly in the blood of 75 healthy controls and 223 HIV-infected individuals. The HIV-seropositive individuals were also classified clinically according to the system recommended by the Centers for Disease Control (CDC), and the CDC classification was correlated with the patients' T cell subset counts. Compared to the control group, the HIV-infected individuals demonstrated an early and sustained increase in the number of CD8+ T cells with median values of CDC groups II, III, and IV C2 twice that observed in the control group. Patients with AIDS had CD8+ T cell counts comparable to those of the control group. The HIV-infected individuals showed a decrease in the number of CD4+ T cells correlating with clinical deterioration of the disease. T cell subset counts significantly distinguished the group of healthy seropositive individuals from those with HIV-related disease, and the group of patients with AIDS from those with other HIV-related opportunistic infections.
