PIGMENTARY DEGENERATION OF RETINA INDUCED BY N-METHYL-N-NITROSOUREA - AN EXPERIMENTAL STUDY IN SYRIAN HAMSTERS
PIGMENTARY DEGENERATION OF RETINA INDUCED BY N-METHYL-N-NITROSOUREA - AN EXPERIMENTAL STUDY IN SYRIAN HAMSTERS
复制标题
DOI：
10.1001/archopht.1967.00980030652017
复制
发表时间：
1967-01-01
影响因子：
--
通讯作者：
HERROLD, KM
中科院分区：
文献类型：
--
作者：
HERROLD, KM
N-甲基-N-亚硝基脲 (NMU) 是一种对实验动物强效致癌物，对叙利亚仓鼠具有视网膜毒性作用。六只动物每周接受 2 次 5 毫克剂量的 NMU 静脉注射，其他 6 只动物接受单次 5 毫克剂量。视网膜变化相当均匀且是双侧的。 7 天时观察到的最早的病变由局限于外核层的拱廊组成。色素上皮显示出退行性变化。后来，棒和外核层遭到广泛破坏。末期由视网膜的薄残余物和与脉络膜直接接触的减弱的内核层组成。视网膜内有色素迁移。视神经和包括晶状体在内的眼前部结构未见异常。
N-methyl-N-nitrosourea (NMU), a potent carcinogen in laboratory animals, has a retinotoxic effect in Syrian hamsters. Six animals received 2 5-mg doses of NMU intravenously at weekly intervals and 6 other animals received a single 5-mg dose. The retinal changes were fairly uniform and bilateral. The earliest lesion, observed at 7 days consisted of arcades confined to the outer nuclear layer. The pigment epithelium revealed degenerative changes. Later there was widespread destruction of the rods and outer nuclear layer. The end stage consisted of a thin remnant of retina with an attenuated inner nuclear layer in direct contact with the choroid. There was intraretinal migration of pigment. The optic nerve and the anterior ocular structures including the lens showed no abnormality.