Contribution of Shape Features to Intradiscal Pressure and Facets Contact Pressure in L4/L5 FSUs: An In-Silico Study.
Contribution of Shape Features to Intradiscal Pressure and Facets Contact Pressure in L4/L5 FSUs: An In-Silico Study.
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DOI：
10.1007/s10439-022-03072-2
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发表时间：
2023-01
影响因子：
3.8
通讯作者：
Taylor, Zeike A.
中科院分区：
文献类型：
--
作者：
Kassab-Bachi, Amin;Ravikumar, Nishant;Wilcox, Ruth K.;Frangi, Alejandro F.;Taylor, Zeike A.
关键词：
脊柱的有限元模型(FEM)通常使用有限数量的简化几何。然而，脊柱的几何特征是决定其有限元结果的重要因素。脊柱节段的形状和其生物力学响应之间的联系已经被研究，但形状特征的协方差被省略了。我们使用基于主成分(PCA)的统计形状建模(SSM)方法来研究形状特征对轴向压缩下合成L4/L5功能脊柱单位的盘内压力(IDP)和小关节接触压力(FCP)的贡献。我们量化了有限元结果中的不确定性，以及各个形状振型对结果的贡献。这种参数化方法能够捕捉真实人群中相关解剖特征的可变性，并对合理的合成几何进行采样。在用于训练SSM的特定受试者队列中，第一形状模式()解释了22.6%的形状变异，并且与IDP(17%)和FCP(11%)具有最大的相关性和贡献。()的几何变异最大的是环核比。本文的在线版本包含可用的补充材料10.1007/s10439-022-03072-2。
Finite element models (FEMs) of the spine commonly use a limited number of simplified geometries. Nevertheless, the geometric features of the spine are important in determining its FEM outcomes. The link between a spinal segment’s shape and its biomechanical response has been studied, but the co-variances of the shape features have been omitted. We used a principal component (PCA)-based statistical shape modelling (SSM) approach to investigate the contribution of shape features to the intradiscal pressure (IDP) and the facets contact pressure (FCP) in a cohort of synthetic L4/L5 functional spinal units under axial compression. We quantified the uncertainty in the FEM results, and the contribution of individual shape modes to these results. This parameterisation approach is able to capture the variability in the correlated anatomical features in a real population and sample plausible synthetic geometries. The first shape mode () explained 22.6% of the shape variation in the subject-specific cohort used to train the SSM, and had the largest correlation with, and contribution to IDP (17%) and FCP (11%). The largest geometric variation in () was in the annulus-nucleus ratio. The online version of this article contains supplementary material available 10.1007/s10439-022-03072-2.
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