Ordering and lyotropic behavior of a silicon-supported cationic and neutral lipid system studied by neutron reflectivity
Ordering and lyotropic behavior of a silicon-supported cationic and neutral lipid system studied by neutron reflectivity
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通过中子反射率研究硅支撑的阳离子和中性脂质体系的有序和溶致行为
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
R. Felici
中科院分区：
文献类型：
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作者：
F. Domenici;C. Castellano;A. Congiu;G. Pompeo;R. Felici
两亲性脂质膜在固体载体上的自组装允许对重要的生物模型系统（如载体脂质膜）进行结构研究，以改善非病毒基因治疗中的DNA转染。本文采用自旋镀膜技术研究了由二油基磷脂酰胆碱（DOPC）和二甲基二十八烷基溴化铵（DDAB）组成的二元脂质体系沉积在[100]硅载体上的中子反射率。我们强调了它们在饱和氧化氘（D2O）蒸汽下的溶变行为，从而指出脂质混合物是由非相互作用的DOPC和DDAB的平面片层双层组成的有序结构域。
Self-assembling of amphipathic lipid films on solid support allows the structural investigation of important biological model systems, such as the vectorlike lipid membranes, in order to improve DNA transfection in nonviral gene therapy. We present a neutron reflectivity study of a binary lipid system composed of dioleoylphosphatidylcholine (DOPC) and dimethyldioctadecylammonium bromide (DDAB) deposited on [100] silicon support by means of spin coating technique. We underline their lyotropic behavior under saturated deuterium oxide (D2O) vapor thus pointing out that the lipid mixture is organized in ordered domains composed of plane lamellar bilayers of noninteractive DOPC and DDAB.
影响因子：
3.4
作者：
Hui, SW;Langner, M;Chan, K
通讯作者：
Chan, K