RAFT Synthesis and DNA Binding of Biodegradable, Hyperbranched Poly(2-(dimethylamino)ethyl Methacrylate
RAFT Synthesis and DNA Binding of Biodegradable, Hyperbranched Poly(2-(dimethylamino)ethyl Methacrylate
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DOI：
10.1021/ma900865c
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发表时间：
2009-06
期刊：
影响因子：
5.5
通讯作者：
Lei Tao;Jingquan Liu;B. Tan;T. P. Davis
中科院分区：
文献类型：
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作者：
Lei Tao;Jingquan Liu;B. Tan;T. P. Davis
进行了一项研究，以证明可生物降解的超支化阳离子聚合物聚（2-（二甲氨基）甲基丙烯酸乙酯）（PDMAEMA）的可逆加成-断裂链转移（RAFT）合成。选择RAFT技术来控制聚合过程，获得链长相似且低毒性的低分子量支化低聚物。采用可生物降解的二硫化物基二甲基丙烯酸酯（DSD-MA），1, 2-双（2-（3-甲基丁-1, 3-二烯-2-基氧基）乙基）二硫烷作为交联剂，将支化低聚物连接成超支化结构，聚合物中的每个支化点通过二硫键连接。链转移剂（CTA），2-（（2-（甲基丙烯酰氧基）乙基）二硫基）乙基4-氰基-4-（苯基硫代硫代）戊酸酯是由2-（（2-羟乙基）二硫基）乙基-4-氰基-4-（苯基硫代硫代）戊酸酯和 三乙胺 (TEA) 存在下的甲基丙烯酰氯。
A study was conducted to demonstrate the reversible addition-fragmentation chain transfer (RAFT) synthesis of a biodegradable hyperbranched cationic polymer, poly (2-(dimethylamino) ethyl methacrylate)(PDMAEMA). The RAFT technique was selected to control the polymerization process and obtain low molecular weight branch oligomers with similar chain lengths and low toxicity. A biodegradable disulfide-base dimethacrylate (DSD-MA), 1, 2-bis (2-(3-methylbuta-1, 3-dien-2-yloxy) ethyl) disulfane was employed as a cross-link agent to link branched oligomers into hyperbranched structures, with each branch point in the polymer linked by a disulfide bond. Chain transfer agent (CTA), 2-((2-(methacryloyloxy) ethyl) disulfanyl) ethyl 4-cyano-4-(phenylcarbonothioylthio) pentanoate was prepared by the reaction between 2-((2-hydroxyethyl) disulfanyl) ethyl-4-cyano-4-(phenylcarbonothioylthio) pentanoate and methacryloyl chloride in the presence of triethlamine (TEA).