MRI findings in children with school problems who had been exposed prenatally to alcohol
MRI findings in children with school problems who had been exposed prenatally to alcohol
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DOI：
10.1017/s0012162201001748
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发表时间：
2002-02-01
影响因子：
3.8
通讯作者：
Valanne, L
中科院分区：
文献类型：
--
作者：
Autti-Rämo, I;Autti, T;Valanne, L
这项研究调查了17名有不同持续时间的产前酒精暴露的儿童(9名男性，8名女性；平均年龄13岁)。这项研究的目的是通过核磁共振检测特定的大脑形态变化，并看看这些发现是否与特定的认知缺陷有关。在17名儿童中，有5名仅在怀孕前三个月曾大量饮酒(每周饮酒超过10杯)；4名在怀孕前和中期接触过酒精；8名在整个怀孕期间接触过酒精。5名儿童患有与酒精有关的神经行为障碍，7名儿童被诊断为胎儿酒精影响，5名儿童被诊断为胎儿酒精综合症。观察到10名儿童后部蠕虫发育不良，另有1名儿童后部蠕虫畸形。5名儿童有发育不良的小脑半球。在两名儿童中观察到了胼胝体发育不全。3例患儿海马区较小，6例皮质沟较宽。没有特定的结构异常与特定的神经心理缺陷相关。在这项研究中，蚯蚓发育的偏差是产前酒精暴露影响的最敏感的形态指标。它在每个诊断组中都可见，包括仅在怀孕前三个月接触过这种病毒的儿童。
This study examined 17 children (nine males, eight females; mean age 13 years) with prenatal alcohol exposure of various durations. The aim of the study was to detect specific brain morphological alterations by means of MRI and to see if findings correlated with particular cognitive deficits. Of the 17 children, five had been exposed to heavy maternal consumption of alcohol (over 10 drinks/week) during the first trimester only; four had been exposed during the first and second trimester; and eight had been exposed throughout pregnancy. Five children had alcohol related neurobehavioural disorder, seven were diagnosed as having foetal alcohol effects and five were diagnosed as having foetal alcohol syndrome. Hypoplasia of the vermis was observed in 10 children and malformed posterior vermis in one additional child. Five children had hypoplastic cerebellar hemispheres. Hypoplasia of the corpus callosum was observed in two children. Small hippocampi were observed in three children and wide cortical sulci in six. No specific structural anomaly correlated with a particular neuropsychological deficit. In this study, deviations in the development of the vermis was the most sensitive morphological indicator of the effects of prenatal alcohol exposure. It was seen in every diagnostic group including children who had been exposed during only the first trimester of pregnancy.