ANGIOTENSIN SYNTHESIS IN THE BRAIN AND INCREASED TURNOVER IN HYPERTENSIVE RATS
ANGIOTENSIN SYNTHESIS IN THE BRAIN AND INCREASED TURNOVER IN HYPERTENSIVE RATS
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DOI：
10.1126/science.6879184
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
LANG, RE
中科院分区：
文献类型：
--
作者：
GANTEN, D;HERMANN, K;LANG, RE
大脑中活跃的内源性肾素-血管紧张素系统的证据中缺失的一环是体内中枢神经系统局部血管紧张素合成的证明。描述了从大鼠脑中提取和表征血管紧张素 I 和血管紧张素 II。当转化酶抑制剂卡托普利在体内阻断血管紧张素 II 的转化时，高血压大鼠体内血管紧张素 I 的积累会增加。
The missing link in the evidence for an active endogenous renin-angiotensin system in the brain was the demonstration of local angiotensin synthesis in the CNS in vivo. The extraction and characterization of angiotensin I and angiotensin II from the brain of rats is described. The accumulation of angiotensin I was enhanced in hypertensive rats when the conversion to angiotensin II was blocked in vivo by the converting enzyme inhibitor captopril.