Optic radiation involvement in optic pathway gliomas in neurofibromatosis
Optic radiation involvement in optic pathway gliomas in neurofibromatosis
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DOI：
10.1016/j.ajo.2003.09.055
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发表时间：
2004-03-01
影响因子：
4.2
通讯作者：
Sutton, LN
中科院分区：
文献类型：
--
作者：
Liu, GT;Brodsky, MC;Sutton, LN
目得：1型神经纤维瘤病（NF-1）中的视路胶质瘤（毛细胞星形细胞瘤）通常累及视神经、视交叉或视束。设计：本文描述了7例NF-1伴神经胶质瘤的患者，这些神经胶质瘤除了累及视神经外，还累及膝状体前视神经通路。方法：对作者之一（G.T.L.）从1993年7月到2001年10月在费城儿童医院。确定了膝状体前视路受累和视放射的患者。从2001年11月至2003年2月，前瞻性地寻找患者。还从另一位作者（M.C.B.）的实践中发现了一些案例。结果：费城儿童医院的4例患者（1993年7月至2001年10月共83例NF-1/视路胶质瘤中的3例，1例前瞻性）和阿肯色州儿童医院的3例被确定。两例患者在颞叶或顶叶的白色物质内有扩大的肿块病变，组织病理学证实为毛细胞型星形细胞瘤。其他5例影像学检查显示有视神经放射，但未进行活检。在三个情况下，视力为20/200或更差的每只眼睛。结论：NF-1视路胶质瘤可能很少涉及的视放射。在神经纤维瘤病-1患者中，视神经放射可能是更具侵袭性的视神经通路胶质瘤的信号。(C)2004年，Elsevier Inc. All rights reserved.
PURPOSE: Optic pathway gliomas (pilocytic astrocytomas) in neurofibromatosis type 1 (NF-1) typically involve some combination of the optic nerves, chiasm, or optic tracts. Involvement of the optic radiations is rare.DESIGN: This paper describes seven patients with NF-1 with gliomas involving the pregeniculate optic pathway in addition to the optic radiations.METHODS: A retrospective database review was made of all patients with NF-1 and optic pathway gliomas seen by one of the authors (G.T.L.) at the Children's Hospital of Philadelphia from July 1993 to October 2001. Patients with involvement of pregeniculate optic pathway and the optic radiations were identified. From November 2001 to February 2003, patients were sought prospectively. Cases were also identified from the practice of another author (M.C.B.) at Arkansas Children's Hospital.RESULTS: Four patients from Children's Hospital of Philadelphia (three of 83 total NF-1/optic pathway gliomas from July 1993 to October 2001 and one prospectively) and three from Arkansas Children's Hospital were identified. Two had expanding mass lesions within the white matter of the temporal or parietal lobes, which were histopathologically demonstrated to be pilocytic astrocytomas. The other five had radiographic involvement of the optic radiations but did not undergo biopsy. In three of the cases the vision was 20/200 or worse in each eye.CONCLUSIONS: Optic pathway gliomas in NF-1 may rarely involve the optic radiations. Optic radiation in, volvement may signal a more aggressive optic pathway glioma in patients with neurofibromatosis-1. (C) 2004 by Elsevier Inc. All rights reserved.