SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children.
SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children.
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DOI：
10.1016/j.clim.2022.109106
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发表时间：
2022-10
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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儿童多系统炎症综合征是发生在儿童人群中的SARS-CoV-2感染的严重并发症。我们试图通过与新冠肺炎和儿科高炎性综合症的比较，来确定MISC中T细胞反应的特征。MIS-C不同于新冠肺炎和高炎症综合征，是由于表达TRBV11-2的T细胞的扩增，而该T细胞与HLA型无关。经聚合酶链式反应和血清学检测为SARS-CoV2阴性的MISC患儿，未见V-β偏斜。与恢复期的新冠肺炎相比，在SARS-CoV-2多肽刺激下，MIS-C患儿的T细胞活化比例没有差异。SARS-CoV-2特异性TCR的出现频率及其所识别的抗原在MIS-C和新冠肺炎中具有可比性。V-β11-2+T细胞的扩增是实验室确诊的非典型肺炎患者的特异性生物标志物。患有MIS-C的儿童对SARS-CoV-2有很强的抗原特异性T细胞反应。
Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infections that occurs in the pediatric population. We sought to characterize T cell responses in MIS-C compared to COVID-19 and pediatric hyperinflammatory syndromes. MIS-C was distinct from COVID-19 and hyperinflammatory syndromes due to an expansion of T cells expressing TRBV11–2 that was not associated with HLA genotype. Children diagnosed with MIS-C, but who were negative for SARS-CoV-2 by PCR and serology, did not display Vβ skewing. There was no difference in the proportion of T cells that became activated after stimulation with SARS-CoV-2 peptides in children with MIS-C compared to convalescent COVID-19. The frequency of SARS-CoV-2-specific TCRs and the antigens recognized by these TCRs were comparable in MIS-C and COVID-19. Expansion of Vβ11–2+ T cells was a specific biomarker of MIS-C patients with laboratory confirmed SARS-CoV-2 infections. Children with MIS-C had robust antigen-specific T cell responses to SARS-CoV-2.
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