Chronic estrogen supplementation following ovariectomy improves the emotional stress-induced cardiovascular responses by indirect action on the nervous system and by direct action on the heart
Chronic estrogen supplementation following ovariectomy improves the emotional stress-induced cardiovascular responses by indirect action on the nervous system and by direct action on the heart
复制标题
DOI：
10.1253/circj.71.565
复制
发表时间：
2007-04-01
影响因子：
3.3
通讯作者：
Beppu, Shintaro
中科院分区：
文献类型：
--
作者：
Ueyama, Takashi;Ishikura, Fuminobu;Beppu, Shintaro
背景Takotsubo心肌病是由情绪或身体压力引起的，尤其是在绝经后的妇女中。方法与结果比较了去卵巢大鼠(OVX)和去卵巢加雌激素(OVX+E)大鼠在束缚应激(IMO)条件下左室收缩的变化。异丙酚复合全身麻醉对去势大鼠和去卵巢+去卵巢大鼠左室收缩功能均有损害作用，补充雌激素可明显改善异丙肾上腺素所致的心功能障碍，显着减轻血压和心率的升高。为了了解雌激素的保护机制，比较了细胞活化标志物c-fos mRNA的表达。并对心脏保护物质的基因表达进行了研究。在OVX+E组，下丘脑室旁核、肾上腺和左心室的c-FOS基因表达水平显著降低，提示雌激素水平的增加减弱了情绪应激引起的下丘脑-交感-肾上腺从中枢神经系统向靶器官的流出。在OVX+E组，热休克蛋白70和心钠素的表达显著增强。结论补充雌激素可能通过间接作用于神经系统和直接作用于心脏，部分阻止情绪应激诱导的心血管反应。
Background Takotsubo cardiomyopathy is triggered by emotional or physical stress especially in postmenopausal women. A reduction in estrogen levels following menopause might underlie the high incidence of takotsubo cardiornyopathy.Methods and Results The left ventricular contraction between ovariectomized rats (OVX) and OVX with estrogen supplementation (OVX+E) while subjected to immobilization stress (IMO) was compared. The IMO in combination with general anesthesia impaired the left ventricular contraction in both OVX and OVX+E. Estrogen supplementation tended to improve the IMO-induced cardiac dysfunction and significantly attenuated the increase of blood pressure and heart rate. To understand the protective mechanism of estrogen, the expression of c-fos mRNA, a marker of cellular activation was compared. The mRNA expression of cardioprotective substances in the heart was also investigated. In the OVX+E, the levels of c-fos mRNA were significantly decreased in the paraventricular hypothalamic nucleus, adrenal gland and left ventricle, suggesting that an increase of estrogen attenuates the emotional stress-induced hypothalamo-sympatho-adrenal outflow from the central nervous system to the target organs. An expression of heat shock protein 70 and atrial natriuretic peptide 'was significantly augmented in the OVX+E.Conclusions These data suggest that estrogen supplementation partially prevents emotional stress-induced cardiovascular responses both by indirect action on the nervous system and by direct action on the heart.