Biologically inspired synthesis of bone-like composite: Self-assembled collagen fibers/hydroxyapatite nanocrystals
Biologically inspired synthesis of bone-like composite: Self-assembled collagen fibers/hydroxyapatite nanocrystals
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DOI：
10.1002/jbm.a.10039
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发表时间：
2003-11-01
影响因子：
4.9
通讯作者：
Falini, G
中科院分区：
文献类型：
--
作者：
Tampieri, A;Celotti, G;Falini, G
用具有模仿自然组织的组成、结构和生物学特征的移植材料和组织工程产品替代骨组织是一个需要追求的目标。采用仿生合成方法制备了羟基磷灰石纳米晶体和自组装型胶原纤维组成的新型骨样复合材料。我们使用了一种受生物学启发的方法，证明了生物系统在分子水平上存储和处理信息。采用了两种不同的方法：将合成羟基磷灰石分散在无端肽的胶原分子溶液中，以及在重组胶原纤维的组装过程中将羟基磷灰石直接成核。实验了不同的制备工艺，对复合材料进行了全面的表征和比较。直接成核得到的复合材料显示出无机组分和蛋白质组分的密切相互作用，改变了磷灰石相，使其组成、形态和结构与天然骨的矿物组分相似。(C) 2003 Wiley期刊有限公司
Replacement of bone tissue by graft materials and products of tissue engineering having composition, structure, and biological features that mimic natural tissue is a goal to be pursued. A biomimetic synthesis was performed to prepare new bone-like composites constituted of hydroxyapatite nanocrystals and self-assembled type I collagen fibers. We used a biological inspired approach that proved that the biological systems stored and processed information at the molecular level. Two different methodologies were used: dispersion of synthetic hydroxyapatite in telopeptides free collagen molecules solution and direct nucleation of hydroxyapatite into reconstituted collagen fibers during their assembling. The different preparation techniques were experimented then the composites thoroughly characterized and compared. Composite obtained by direct nucleation showed an intimated interaction of the inorganic and proteic components, which modified the apatitic phase and made its composition, morphology and structure similar to the mineral component of natural bone. (C) 2003 Wiley Periodicals, Inc.