Effect of endometrial thickness on ectopic pregnancy in frozen embryo transfer cycles: an analysis including 17,244 pregnancy cycles
Effect of endometrial thickness on ectopic pregnancy in frozen embryo transfer cycles: an analysis including 17,244 pregnancy cycles
复制标题
冷冻胚胎移植周期中子宫内膜厚度对异位妊娠的影响：一项包含 17,244 个妊娠周期的分析
DOI：
10.1016/j.fertnstert.2019.09.003
复制
发表时间：
2020-01-01
影响因子：
6.7
通讯作者：
Kuang, Yanping
中科院分区：
文献类型：
--
作者：
Liu, Hongfang;Zhang, Jie;Kuang, Yanping
目的：研究子宫内膜厚度（EMT）是否影响冷冻胚胎移植（FET）周期中异位妊娠（EP）的发生率。设计：回顾性队列研究。设置：学术三级医疗中心。患者：2010年1月至2017年12月期间，共招募了16，556名患者，包括16，701名宫内，488名异位，45例FET后异位妊娠周期。干预：无。主要结局指标：EP为主要结局。EMT是主要的测量变量。结果：在调整混杂因素后，EMT仍是EP的独立危险因素，其差异有统计学意义。与EMT>= 14 mm的女性相比，EMT范围为7-7.9、8-9.9和10-11.9 mm的女性aOR分别为2.70（95%置信区间[CI]，1.65-4.40）、2.06（95% CI，1.33-3.20）和1.66（95% CI，1.07-2.58）。激素替代治疗的子宫内膜准备在FET增加的风险EP调整后的混淆variables. Conclusions（S）：EMT是成反比的EP率在FET周期，因此是一个潜在的定量指标的子宫内膜容受性和子宫收缩性在FET周期。EMT值的预测有效性有待进一步研究。((C)2019年由美国生殖医学学会（American Society for Reproductive Medicine）
Objective: To investigate whether endometrial thickness (EMT) influences the incidence of ectopic pregnancy (EP) in frozen embryo transfer (FET) cycles.Design: Retrospective cohort study.Setting: Academic tertiary-care medical center.Patient(s): A total of 16,556 patients were enrolled between January 2010 and December 2017, comprising 16,701 intrauterine, 488 ectopic, and 45 heterotopic pregnancy cycles after FET.Intervention(s): None.Main Outcome Measure(s): EP was the primary outcome. EMT was the main measured variable. Data were analyzed with the binary logistic general estimating equations model to calculate the adjusted odds ratio (aOR) for EP.Result(s): After adjusting for confounders, EMT remained statistically significant as an independent risk factor for EP. Compared with women with an EMT of >= 14 mm, the aORs for women with EMT in the ranges 7-7.9, 8-9.9, and 10-11.9 mm were 2.70 (95% confidence interval [CI], 1.65-4.40), 2.06 (95% CI, 1.33-3.20), and 1.66 (95% CI, 1.07-2.58), respectively. Hormone replacement treatment for endometrial preparation during FET increased the risk of EP after adjustment for confounding variables.Conclusion(s): EMT is inversely proportional to EP rate in FET cycles and is therefore a potential quantitative marker of endometrial receptivity and uterine contractibility in an FET cycle. The predictive validity of EMT value must be evaluated in further studies. ((C) 2019 by American Society for Reproductive Medicine.)