3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors
3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors
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DOI：
10.1016/j.bmcl.2005.09.051
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发表时间：
2006-01-01
影响因子：
2.7
通讯作者：
Kessler, H
中科院分区：
文献类型：
--
作者：
Weide, T;Arve, L;Kessler, H
在寻找新型药物支架的研究过程中，我们合成了一系列3-取代中氮茚-1-腈衍生物。它们中的一些显示出对与感染性疾病有关的MPtpA/MPtpB磷酸酶的活性。本文报道了一系列中氮茚类化合物的固相合成及其抗磷酸酶活性。(c)2005爱思唯尔有限公司保留所有权利。
In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines. (c) 2005 Elsevier Ltd. All rights reserved.