Pulse-chase studies of the POMC/beta-endorphin system in the pituitary of acutely and chronically stressed rats.
Pulse-chase studies of the POMC/beta-endorphin system in the pituitary of acutely and chronically stressed rats.
复制标题
急性和慢性应激大鼠垂体中 POMC/β-内啡肽系统的脉冲追踪研究。
DOI：
10.1016/0024-3205(82)90114-x
复制
发表时间：
1982
期刊：
影响因子：
6.1
通讯作者：
Akil,H
中科院分区：
文献类型：
--
作者：
Shiomi,H;Akil,H
为探讨应激是否引起大鼠前叶(AL)和中后叶(IPL)阿片黑素皮质素原(POMC)系统的生化变化。在一系列脉冲追逐实验中，急性应激导致急性白血病细胞POMC生物合成增加，半衰期缩短。然而，当动物受到慢性应激时，AL不再表现出POMC合成的增加。另一方面，在IPL中，急性应激没有产生任何生化变化，但慢性应激导致POMC合成增加，半衰期缩短。这些结果提示，急性和/或慢性应激对AL和IPL的影响是相反的，AL中的POMC系统可能在应激诱导的镇痛中发挥重要作用。
Experiments were carried out to determine whether stress induces biochemical changes in the pro-opiomelanocortin (POMC) system in anterior (AL) and intermediate-posterior lobe (IPL) of rat. In a series of pulse-chase experiments, acute stress led to an increase in POMC biosynthesis and shorter half-life in AL. However, when the animals were chronically stressed, the AL no longer exhibited increased POMC synthesis. On the other hand, in the IPL, acute stress did not produce any biochemical changes, but chronic stress led to an increase in POMC synthesis and shorter half-life. These data suggest that AL and IPL are affected by acute and/or chronic exposure to stress in opposite directions and that the POMC system in AL may play an important role in stress-induced analgesia.