The Drosophila retinoid X receptor homolog ultraspiracle functions in both female reproduction and eye morphogenesis.
The Drosophila retinoid X receptor homolog ultraspiracle functions in both female reproduction and eye morphogenesis.
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发表时间：
1992-06
期刊：
影响因子：
4.6
通讯作者：
A. Oro;M. Mckeown;R. Evans
中科院分区：
文献类型：
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作者：
A. Oro;M. Mckeown;R. Evans
超气门（ultraspicacle，usp）编码RXR（人维甲酸X受体）的果蝇同源物。为了研究RXR亚家族成员在发育中的功能，我们对USP突变体进行了表型分析。USP在多种组织中发生的功能的多个发育阶段是必需的。USP在眼睛-触角的成虫盘中是正常眼睛形态发生所必需的，在成年雌性的体细胞和生殖系组织中是受精、蛋壳形态发生和胚胎发育所必需的。具有明显腹背极性的不寻常的凹陷眼表型似乎是由位于眼睛和触角原基之间的成虫盘细胞缺乏usp功能引起的。usp功能包括细胞自主和非细胞自主成分，表明usp控制细胞间通讯和细胞分化的重要因子的产生。这些usp信号通路在发育中的脊椎动物组织中与类固醇和类维生素A的作用机制相似。
Ultraspiracle (usp) encodes the Drosophila cognate of RXR, the human retinoid X receptor. To examine how RXR subfamily members function in development, we have undertaken a phenotypic analysis of usp mutants. usp is required at multiple stages of development for functions that occur in a wide variety of tissues. usp is required in the eye-antennal imaginal disc for normal eye morphogenesis and in the somatic and germline tissues of adult females for fertilization, eggshell morphogenesis and embryonic development. An unusual sunken eye phenotype with marked ventral-dorsal polarity appears to be caused by a lack of usp function in the imaginal disc cells that reside between the eye and antennal anlage. The usp functions include cell autonomous and non-cell autonomous components, suggesting that usp controls the production of factors important for both cell-cell communication and cellular differentiation. These usp signalling pathways have mechanistic parallels to steroid and retinoid action in developing vertebrate tissues.