Prenatal and neonatal androgen exposure interact to affect sexual differentiation in female rats.
Prenatal and neonatal androgen exposure interact to affect sexual differentiation in female rats.
复制标题
产前和新生儿雄激素暴露相互作用，影响雌性大鼠的性别分化。
DOI：
10.1037//0735-7044.102.1.61
复制
发表时间：
1988
影响因子：
1.9
通讯作者：
Ward,IL
中科院分区：
文献类型：
--
作者：
Hoepfner,BA;Ward,IL
在妊娠第17.5天和第18.5天向大鼠注射油，或在第15.5天和第16.5天、或第17.5天和第18.5天、或第19.5天和第20.5天注射2 mg丙酸睾酮（TP）。雌性后代在受孕后第25天给予油或5 μg TP。在仅在产前个体发育期间暴露于TP的雌性动物中，在妊娠第17.5-28.5天接受治疗的雌性动物中显示脊柱前凸行为的比例低于对照组。出生后TP单独不影响脊柱前凸。然而，所有接受产前和产后TP相结合的组表现出受损的发情模式。形态的几个组件的发展也受到不同的雄激素暴露的时间。这些数据表明，在大鼠的性行为和生殖形态的分化的影响，雄激素依赖的过程中，在不同阶段的围产期个体发育的相互作用。此外，可能有一个最佳的胎儿期，在此期间，雄激素化使动物对新生儿发育期间循环的低水平睾酮敏感。（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Rats were injected with oil on Days 17.5 and 18.5 of pregnancy or with 2 mg of testosterone propionate (TP) on Days 15.5 and 16.5, or Days 17.5 and 18.5, or Days 19.5 and 20.5. The female offspring were given oil or 5 μg of TP on Day 25 postconception. Among females exposed to TP only during prenatal ontogeny, a lower proportion of those treated on Days 17.5–28.5 of gestation displayed lordotic behavior than did the control group. Postnatal TP alone did not affect lordosis. However, all groups receiving combined pre-and postnatal TP showed impaired estrous patterns. The development of several components of morphology also was differentially affected by the timing of the androgen exposure. The data suggest that the differentiation of sexual behavior and reproductive morphology in the rat are influenced by an interaction of androgen dependent processes operating at different stages of perinatal ontogeny. Further, there may be an optimal fetal period during which androgenization sensitizes animals to low levels of testosterone circulating during neonatal development.(PsycINFO Database Record (c) 2016 APA, all rights reserved)