Memory impairment in monkeys following lesions limited to the hippocampus.
Memory impairment in monkeys following lesions limited to the hippocampus.
复制标题
仅限于海马体损伤后的猴子记忆障碍。
DOI：
10.1037//0735-7044.100.2.155
复制
发表时间：
1986
影响因子：
1.9
通讯作者：
Squire,LR
中科院分区：
文献类型：
--
作者：
Zola-Morgan,S;Squire,LR
这项研究解决了海马体损伤产生的记忆障碍有多严重的问题。在延迟不匹配样本任务中测试了有局限性海马损伤的猴子，这是一种对人类健忘症敏感的识别记忆测试。猴在接受延迟不匹配样本任务培训之前，未接受任何术前培训，也未获得任何术后经验。观察到明显的不足。这些结果与以前的研究结果一起，还提供了有关可能影响海马损伤后记忆障碍水平的几个因素的作用的信息。损伤程度似乎不是由于以下任何因素造成的：术后测试时间、既往术后测试、手术技术、种属差异或行为训练方法。然而，术前训练经验似乎确实可以降低损伤的严重程度，这一因素可能解释了与海马病变相关的记忆损伤有时非常轻微的观察结果。最后，最近的情况下，人类健忘症的研究在这个实验室进行了讨论，其中双边病变仅限于一部分的海马产生了良好的记录记忆缺陷。
This study addressed the question of how severe a memory impairment is produced by a lesion limited to the hippocampus. Monkeys with circumscribed hippocampal lesions were tested on the delayed-nonmatching-to-sample task, a test of recognition memory that is sensitive to amnesia in humans. Monkeys were given no preoperative training and were given no postoperative experience prior to training on the delayed-nonmatching-to-sample task. A marked deficit was observed. The results, taken together with those from previous studies, also provided information about the role of several factors that could potentially influence the level of memory impairment following hippocampal lesions. The level of impairment does not appear to be due to any of the following factors: time of testing after surgery, prior postoperative testing, surgical techniques, species differences, or behavioral training methods. However, preoperative training experience does appear to reduce the severity of the impairment, and this factor may account for the observation that the memory impairment associated with hippocampal lesions is sometimes very mild. Finally, a recent case of human amnesia studied in this laboratory is discussed in which a bilateral lesion limited to a portion of the hippocampus produced a well-documented memory deficit.