Prenatal Exposure to Perfluoroalkyl Substances: Infant Birth Weight and Early Life Growth.
Prenatal Exposure to Perfluoroalkyl Substances: Infant Birth Weight and Early Life Growth.
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DOI：
10.1097/ee9.0000000000000010
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发表时间：
2018-06-01
期刊：
影响因子：
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通讯作者：
Braun, Joseph M
中科院分区：
文献类型：
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作者：
Shoaff, Jessica;Papandonatos, George D;Braun, Joseph M
背景：产前全氟烷基物质（PFAS）暴露与出生体重减轻和儿童过度肥胖有关，但PFAS与早期生命生长之间的关系尚不清楚。目的：确定产前PFAS暴露是否与出生体重、体成分和2岁前的生长有关。方法：在一项来自俄亥俄州辛辛那提市的妇女及其子女的前瞻性队列研究中，我们量化了孕妇血清中的全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟丙酮酸（PFNA）和全氟己烷磺酸（PFHxS）。在调整了社会人口统计学、围产期、营养和环境因素后，我们使用线性回归来估计PFAS与出生体重z分数（n=345）的相关性，并使用线性混合模型来估计4周、1岁和2岁时重复体重和长度/身高测量（n=334）的相关性。结果：我们发现PFAS与婴儿出生体重之间无显著负相关。例如，PFOA每增加log2，出生体重z评分就会降低0.03个标准差（95% CI:-0.17, 0.10）。与出生体重的相关性相比，我们观察到PFAS与儿童4周到2岁的人体测量之间存在更强的相关性。例如，PFOA每增加log2， BMI z-score就会降低0.12个标准差（95% CI: -0.25, 0.01）。我们没有观察到与PFAS相关的生长速率有任何差异。结论：我们观察到产前血清PFAS浓度与2岁前的人体测量呈负相关。产前血清PFAS浓度与生命前2年的生长速率无关。
BACKGROUND: Prenatal perfluoroalkyl substance (PFAS) exposure has been associated with reduced birth weight and excess child adiposity, but the relationship between PFAS and early life growth is unknown.OBJECTIVE: To determine if prenatal PFAS exposure was associated with birth weight, body composition and growth until 2 years of age.METHODS: In a prospective cohort of women and their children from Cincinnati, OH, we quantified perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS) in pregnant women's serum. We used linear regression to estimate associations of PFAS with birth weight z-scores (n=345) and linear mixed models to estimate associations with repeated weight and length/height measurements (n=334) at ages 4 weeks and 1 and 2 years, after adjusting for sociodemographic, perinatal, nutritional, and environmental factors.RESULTS: We found non-significant inverse associations between PFAS and infant birth weight. For example, each log2 increase in PFOA was associated with a 0.03 standard deviation reduction in birth weight z-score (95% CI:-0.17, 0.10). Compared to associations with birth weight, we observed stronger associations between PFAS and child anthropometry from 4 weeks to 2 years. For instance, each log2 increase in PFOA was associated with a 0.12 standard deviation decrease in BMI z-score (95% CI: -0.25, 0.01). We did not observe any differences in growth rate associated with PFAS.CONCLUSION: We observed inverse associations between prenatal serum PFAS concentrations and anthropometry until age 2 years. Prenatal serum PFAS concentrations were not associated with growth rate in the first 2 years of life.