Isoniazid-related copper(II) and nickel(TI) complexes with antimycobacterial in vitro activity.: Part 9
Isoniazid-related copper(II) and nickel(TI) complexes with antimycobacterial in vitro activity.: Part 9
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DOI：
10.1016/s0960-894x(00)00058-5
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发表时间：
2000-04-03
影响因子：
2.7
通讯作者：
Vigorita, MG
中科院分区：
文献类型：
--
作者：
Bottari, B;Maccari, R;Vigorita, MG
本文以抗结核药物异烟肼（Isoniazid）所合成的异烟酰腙1（Isonicotinoylhydrazones 1）为单阴离子配体，合成了化学计量的Cu（Ⅱ）_2和Ni（Ⅱ）_3八面体配合物[MeL_2（H_2 O）（2）]。配合物2a、2b、2f、3b、3d和3g显示出小于或等于0.2 μ g/mL的MIC值。(C)2000爱思唯尔科技有限公司版权所有。
Isonicotinoylhydrazones 1, obtained by the primary antituberculous agent Isoniazid, have been used as monoanionic ligands (L) to prepare copper(II) 2 and nickel(II) 3 octahedral complexes of stoichiometry [MeL2(H2O)(2)] Their antimycobacterial in vitro activity was evaluated against Mycobacterium tuberculosis H37Rv in comparison with the ligands. Complexes 2a, 2b, 2f, 3b, 3d and 3g displayed MIC values less than or equal to 0.2 mu g/mL. (C) 2000 Elsevier Science Ltd. All rights reserved.