Vascular responses to hypoxia and ischemia.
Vascular responses to hypoxia and ischemia.
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DOI：
10.1161/atvbaha.108.181644
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Semenza GL
中科院分区：
文献类型：
--
作者：
Semenza GL
血管充当输送氧气和营养物质的管道。缺氧诱导因子 1 (HIF-1) 介导对缺氧/缺血的适应性转录反应，包括缺氧细胞表达血管生成细胞因子/生长因子以及血管细胞及其祖细胞表达这些配体的同源受体。 HIF-1 依赖性缺氧反应受损是导致血管对缺血反应受损的一个主要因素，而缺血与衰老和糖尿病相关。
Blood vessels function as conduits for the delivery of O2 and nutrients. Hypoxia-inducible factor 1 (HIF-1) mediates adaptive transcriptional responses to hypoxia/ischemia that include expression of angiogenic cytokines/growth factors by hypoxic cells and expression of cognate receptors for these ligands by vascular cells and their progenitors. Impairment of HIF-1-dependent responses to hypoxia is a major factor contributing to the impaired vascular responses to ischemia that are associated with aging and diabetes.