Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors
Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors
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DOI：
10.1016/j.ejphar.2015.05.015
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发表时间：
2015-09-15
影响因子：
5
通讯作者：
Brauner-Osborne, Hans
中科院分区：
文献类型：
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作者：
Norskov-Lauritsen, Lenea;Brauner-Osborne, Hans
G蛋白偶联受体根据其7个跨膜结构域的同源性分为三类（A、B和C）。C类是具有22种人类受体亚型的最小类别，包括8种代谢型谷氨酸（mGlu（1-8））受体、2种GABA（B）受体（GABA（B1）和GABA（B2））、3种味觉受体（T1 R1 -3）、1种钙敏感（CaS）受体、1种GPCR、C类6组A亚型（GPRC（6））受体和7种孤儿受体。G蛋白偶联受体经历许多翻译后修饰，其调节其结构、功能和/或药理学。在这里，我们回顾了C类G蛋白偶联受体的翻译后修饰的存在及其调节作用，特别关注糖基化，磷酸化，泛素化，SUMO化，二硫键和脂质化。(C)2015 Elsevier B. V.版权所有。
G protein-coupled receptors are divided into three classes (A, B and C) based on homology of their seven transmembrane domains. Class C is the smallest class with 22 human receptor subtypes including eight metabotropic glutamate (mGlu(1-8)) receptors, two GABA(B) receptors (GABA(B1) and GABA(B2)), three taste receptors (T1R1-3), one calcium-sensing (CaS) receptor, one GPCR, class C, group 6, subtype A (GPRC(6)) receptor, and seven orphan receptors. G protein-coupled receptors undergo a number of post-translational modifications, which regulate their structure, function and/or pharmacology. Here, we review the existence of post-translational modifications in class C G protein-coupled receptors and their regulatory roles, with particular focus on glycosylation, phosphorylation, ubiquitination, SUMOylation, disulphide bonding and lipidation. (C) 2015 Elsevier B.V. All rights reserved.