The role of circulating miRNAs in multiple myeloma.
The role of circulating miRNAs in multiple myeloma.
复制标题
循环 miRNA 在多发性骨髓瘤中的作用。
DOI：
10.1007/s11427-015-4969-2
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Liu Jing
中科院分区：
文献类型：
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作者：
Zhang Ji;Xiao XiaoJuan;Liu Jing
多发性骨髓瘤（MM）是一种常见的恶性血液病。MM细胞和骨髓微环境中microRNAs（miRNAs）的失调对MM的发生、发展和MM细胞的耐药性有重要影响。最近，据报道，MM患者血清和血浆含有足够稳定的miRNA特征，并且可以从体液中准确地鉴定和测量循环miRNA。与常规诊断参数相比，循环miRNA谱适用于MM的诊断，并以更高的特异性和灵敏度估计患者进展和治疗结果。本文主要综述了循环miRNA作为MM诊断、预后和预测生物标志物的潜力，并总结了在各种癌症中识别和测量循环miRNA的一般策略和方法。此外，我们还讨论了多发性骨髓瘤中循环miRNAs与细胞遗传学异常和生化参数之间的相关性。
Multiple myeloma (MM) is a common malignant hematological disease. Dysregulation of microRNAs (miRNAs) in MM cells and bone marrow microenviroment has important impacts on the initiation and progression of MM and drug resistance in MM cells. Recently, it was reported that MM patient serum and plasma contained sufficiently stable miRNA signatures, and circulating miRNAs could be identified and measured accurately from body fluid. Compared to conventional diagnostic parameters, the circulating miRNA profile is appropriate for the diagnosis of MM and estimates patient progression and therapeutic outcome with higher specificity and sensitivity. In this review, we mainly focus on the potential of circulating miRNAs as diagnostic, prognostic, and predictive biomarkers for MM and summarize the general strategies and methodologies for identification and measurement of circulating miRNAs in various cancers. Furthermore, we discuss the correlation between circulating miRNAs and the cytogenetic abnormalities and biochemical parameters assessed in multiple myeloma.