Recent advances in eosinophil biology
Recent advances in eosinophil biology
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DOI：
10.1159/000101398
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发表时间：
2007-01-01
影响因子：
2.8
通讯作者：
Hogan, Simon P.
中科院分区：
文献类型：
--
作者：
Hogan, Simon P.
嗜酸性粒细胞是一种多效多功能白细胞，参与多种炎症反应的启动和传播。最近的研究检查嗜酸性粒细胞生物学集中在描绘FIP 1 L1/PDGRF α融合基因诱导的HES的分子基础，参与肿瘤相关嗜酸性粒细胞增多症和EGID中嗜酸性粒细胞募集的分子步骤，以及嗜酸性粒细胞在哮喘中的作用。本文对这些研究进行了综述，重点介绍了这些研究结果对了解嗜酸性粒细胞在疾病中的作用的意义。版权所有（C）2007 S. Karger AG，巴塞尔。
Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRF alpha-fusion gene induced HES, the molecular steps involved in eosinophil recruitment in tumor-associated eosinophilia and EGID, and the role of eosinophils in asthma. In this review, these studies are summarized, focusing on the implications of these findings in the understanding the role of eosinophils in diseases. Copyright (C) 2007 S. Karger AG, Basel.